4-[2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]-N'-[(1E)-phenylmethylene]benzenesulphonohydrazide

Base Information

• Chemical Name: 4-[2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]-N'-[(1E)-phenylmethylene]benzenesulphonohydrazide
• CAS No.: 1346518-16-8
• Molecular Formula: C₂₇H₂₁N₃O₄S
• Molecular Weight: 483.547

Synonyms:4-[2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]-N'-[(1E)-phenylmethylene]benzenesulphonohydrazide

Chemical Property of 4-[2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]-N'-[(1E)-phenylmethylene]benzenesulphonohydrazide

Chemical Property:

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Technology Process of 4-[2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]-N'-[(1E)-phenylmethylene]benzenesulphonohydrazide

There total 5 articles about 4-[2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]-N'-[(1E)-phenylmethylene]benzenesulphonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

4-[2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]benzenesulfonohydrazide (1346518-14-6) + benzaldehyde (100-52-7) → 4-[2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]-N'-[(1E)-phenylmethylene]benzenesulphonohydrazide (1346518-16-8)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 20 ℃;

DOI:10.1016/j.bmc.2011.09.008

Reference yield:

1,8-Naphthalic anhydride (81-84-5) → 4-[2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]-N'-[(1E)-phenylmethylene]benzenesulphonohydrazide (1346518-16-8)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 6 h / Reflux

2: chlorosulfonic acid / 0 - 50 °C

3: hydrazine hydrate / methanol / 0.5 h / 0 - 20 °C

4: hydrogenchloride / ethanol; water / 20 °C

With hydrogenchloride; chlorosulfonic acid; hydrazine hydrate; In methanol; ethanol; water;

DOI:10.1016/j.bmc.2011.09.008

Reference yield:

phenethylamine (64-04-0) → 4-[2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]-N'-[(1E)-phenylmethylene]benzenesulphonohydrazide (1346518-16-8)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 6 h / Reflux

2: chlorosulfonic acid / 0 - 50 °C

3: hydrazine hydrate / methanol / 0.5 h / 0 - 20 °C

4: hydrogenchloride / ethanol; water / 20 °C

With hydrogenchloride; chlorosulfonic acid; hydrazine hydrate; In methanol; ethanol; water;

DOI:10.1016/j.bmc.2011.09.008

upstream raw materials:

4-[2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]benzenesulfonohydrazide

benzaldehyde

2-(2-phenylethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione

4-[2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]benzenesulphonyl chloride

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