1,8-DIAZA-SPIRO[4.5]DECANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 1,8-DIAZA-SPIRO[4.5]DECANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 885279-92-5
• Molecular Formula: C13H24N2O2
• Molecular Weight: 240.346
• Hs Code.: 2933990090
• Mol file: 885279-92-5.mol

Synonyms:tert-Butyl1,8-diazaspiro[4.5]decane-1-carboxylate;tert-Butyl 4,8-diazaspiro[4.5]decane-4-carboxylate;

Chemical Property of 1,8-DIAZA-SPIRO[4.5]DECANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 0.000108mmHg at 25°C
• Refractive Index: 1.514
• Boiling Point: 337 °C at 760 mmHg
• PKA: 10.70±0.20(Predicted)
• Flash Point: 157.6 °C
• PSA: 41.57000
• Density: 1.07 g/cm³
• LogP: 2.40620
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

1,8-Diazaspiro[4.5]decane-1-carboxylicacidtert-butylester 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-Butyl 1,8-Diazaspiro[4.5]decane-1-carboxylate can derived to use as lysine-?specific demethylase 1 inhibitors (LSD1-?inhibitors).

Technology Process of 1,8-DIAZA-SPIRO[4.5]DECANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 1 articles about 1,8-DIAZA-SPIRO[4.5]DECANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 8-benzyl-1,8-diazaspiro[4.5]decane-1-carboxylate (928034-31-5) → tert-butyl 1,8-diazaspiro[4.5]decane-1-carboxylate (885279-92-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; toluene; at 90 ℃; under 53203.6 Torr;

Reference yield:

C25H24IN2O3Pol + tert-butyl 1,8-diazaspiro[4.5]decane-1-carboxylate (885279-92-5) → C38H47N4O5Pol

Guidance literature:

With potassium phosphate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In ISOPROPYLAMIDE; at 90 ℃; Polystyrene

Reference yield:

tert-butyl 1,8-diazaspiro[4.5]decane-1-carboxylate (885279-92-5) + benzyl chloroformate (501-53-1,94274-21-2) → 8-benzyl 1-tert-butyl 1,8-diazaspiro[4.5]decane-1,8-dicarboxylate (928034-34-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 3.5h;

upstream raw materials:

tert-butyl 8-benzyl-1,8-diazaspiro[4.5]decane-1-carboxylate

Downstream raw materials:

8-benzyl 1-tert-butyl 1,8-diazaspiro[4.5]decane-1,8-dicarboxylate

C₃₈H₄₆N₄O₆

1-[3-(4-chloro-phenoxy)-benzyl]-1,8-diaza-spiro[4.5]decane-8-carboxylic acid pyridin-3-ylamide

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