ethyl 3-hydroxynonanoate

Base Information

• Chemical Name: ethyl 3-hydroxynonanoate
• CAS No.: 26257-80-7
• Molecular Formula: C₁₁H₂₂O₃
• Molecular Weight: 202.294
• Mol file: 26257-80-7.mol

Synonyms:ethyl 3-hydroxynonanoate

Chemical Property of ethyl 3-hydroxynonanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-hydroxynonanoate

There total 2 articles about ethyl 3-hydroxynonanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

heptanal (111-71-7) + ethyl bromoacetate (105-36-2) → ethyl 3-hydroxynonanoate (26257-80-7) + 2-pentyl-2-nonenal (3021-89-4) + 2-Pentyl-1,3-nonanediol-1-monoheptanoate (49562-88-1) + 1-hexyl-2-pentyl-3-hydroxypropyl heptanoate (55109-59-6) + Heptanoic acid 2-(2-bromo-acetoxymethyl)-1-hexyl-heptyl ester (82352-13-4) + 2-pentyl-3-(bromoacetoxy)nonyl heptanoate (82352-12-3)

Guidance literature:

With zinc;

DOI:10.1021/jo00139a010

Reference yield:

heptanal (111-71-7) + n-pentyl methyl ketone (110-43-0) + lithium 1-ethoxyethenolate (56579-97-6) → ethyl 3-hydroxynonanoate (26257-80-7) + 3-hydroxy-3-methyloctanoic acid ethyl ester (85554-68-3)

Guidance literature:

With tetrakis(diethylamido)titanium(IV); multistep reaction; selectivity of Ti(NEt₂)4 as protective agent for carbonyl compounds (preferential protection of the aldehyde); competition between aldehyd and ketone;

DOI:10.1039/c39830000406

Reference yield:

ethyl 3-hydroxynonanoate (26257-80-7) + tert-butylchlorodiphenylsilane (58479-61-1) → C27H40O3Si (1613668-11-3)

Guidance literature:

With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 6h;

DOI:10.1016/j.tetlet.2014.04.119

upstream raw materials:

heptanal

n-pentyl methyl ketone

lithium 1-ethoxyethenolate

ethyl bromoacetate

Downstream raw materials:

ethyl (2E)-non-2-enoate

C₂₇H₄₀O₃Si

Refernces

• 1、 Plattner, Jacob J.,Gawronska, Eva,Rinehart, Kenneth L.. "Glycol Ester Formation in the Reformatsky Reaction". . p. 3440 - 3442. Retrieved 2007/10/02.