2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-(5-pyrimidinylmethyl)-4(1H)-pyrimidinone

Base Information

Chemical Name:2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-(5-pyrimidinylmethyl)-4(1H)-pyrimidinone
CAS No.:1380426-96-9
Molecular Formula:C₂₅H₂₀ClF₃N₄O₃
Molecular Weight:516.907
Hs Code.:

Synonyms:2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-(5-pyrimidinylmethyl)-4(1H)-pyrimidinone

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Chemical Property of 2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-(5-pyrimidinylmethyl)-4(1H)-pyrimidinone

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Technology Process of 2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-(5-pyrimidinylmethyl)-4(1H)-pyrimidinone

There total 6 articles about 2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-(5-pyrimidinylmethyl)-4(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.2%

: 1380426-95-8
2-(4-(4-chloro-3-(trifluoromethyl)phenoxy)phenethoxy)-5-(pyrimidin-5-ylmethyl)pyrimidin-4(1H)-one

: 74-88-4
methyl iodide

: 1380426-96-9
2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-(5-pyrimidinylmethyl)-4(1H)-pyrimidinone

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1380426-96-9
2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-(5-pyrimidinylmethyl)-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 120 °C / Microwave irradiation

2.1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.2: 20 °C

3.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 0 - 20 °C

3.2: 2 h / 50 °C

4.1: tetrahydrofuran / 3 h / 55 °C / Inert atmosphere

5.1: potassium acetate / toluene / 3.03 h / 20 °C / Reflux

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane

With potassium acetate; sodium hydride; potassium carbonate; 9-borabicyclo[3.3.1]nonane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 2.1: Wittig Reaction;

Reference yield:

: 1369254-73-8
4-chloro-3-(trifluoromethyl)phenyl 4-ethenylphenyl ether

: 1380426-96-9
2-{[2-(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)ethyl]oxy}-1-methyl-5-(5-pyrimidinylmethyl)-4(1H)-pyrimidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 0 - 20 °C

1.2: 2 h / 50 °C

2.1: tetrahydrofuran / 3 h / 55 °C / Inert atmosphere

3.1: potassium acetate / toluene / 3.03 h / 20 °C / Reflux

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane

With potassium acetate; 9-borabicyclo[3.3.1]nonane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; toluene;