2-{3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl}propan-2-ol

Base Information

Chemical Name:2-{3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl}propan-2-ol
CAS No.:1278652-40-6
Molecular Formula:C₂₂H₁₉ClN₂O
Molecular Weight:362.859
Hs Code.:

Synonyms:2-{3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl}propan-2-ol

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Chemical Property of 2-{3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl}propan-2-ol

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Technology Process of 2-{3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl}propan-2-ol

There total 5 articles about 2-{3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl}propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1278652-51-9
methyl 3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]benzoate

: 75-16-1
methylmagnesium bromide

: 1278652-40-6
2-{3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl}propan-2-ol

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1278250-09-1
2-(4-bromopyridin-2-yl)-1-(4-chlorophenyl)ethanone

: 1278652-40-6
2-{3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl}propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: mesitylenesulfonylhydroxylamine / dichloromethane / 30 h / 0 - 20 °C

2: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran

3: tetrahydrofuran; diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; mesitylenesulfonylhydroxylamine; caesium carbonate; In tetrahydrofuran; diethyl ether; dichloromethane; water;

Reference yield:

: 22282-99-1
4-bromo-2-methylpyridine

: 1278652-40-6
2-{3-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyridin-5-yl]phenyl}propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 5 - 20 °C / Inert atmosphere

2: mesitylenesulfonylhydroxylamine / dichloromethane / 30 h / 0 - 20 °C

3: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran

4: tetrahydrofuran; diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; mesitylenesulfonylhydroxylamine; caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; dichloromethane; water;