2-Methyl-propane-2-sulfinic acid [3-phenyl-prop-(E)-ylidene]-amide

Base Information

• Chemical Name: 2-Methyl-propane-2-sulfinic acid [3-phenyl-prop-(E)-ylidene]-amide
• CAS No.: 854497-57-7
• Molecular Formula: C₁₃H₁₉NOS
• Molecular Weight: 237.366
• Mol file: 854497-57-7.mol

Synonyms:2-Methyl-propane-2-sulfinic acid [3-phenyl-prop-(E)-ylidene]-amide

Chemical Property of 2-Methyl-propane-2-sulfinic acid [3-phenyl-prop-(E)-ylidene]-amide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-Methyl-propane-2-sulfinic acid [3-phenyl-prop-(E)-ylidene]-amide

There total 1 articles about 2-Methyl-propane-2-sulfinic acid [3-phenyl-prop-(E)-ylidene]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-phenyl-propionaldehyde (104-53-0) + (S)-2-methylpropane-2-sulfinamide (343338-28-3) → 2-Methyl-propane-2-sulfinic acid [3-phenyl-prop-(E)-ylidene]-amide (854497-57-7)

Guidance literature:

With potassium hydrogensulfate; In toluene; at 45 ℃;

DOI:10.1055/s-2005-865234

Reference yield: 89.0%

benzyl (tert-butoxycarbonyl)oxycarbamate + 2-Methyl-propane-2-sulfinic acid [3-phenyl-prop-(E)-ylidene]-amide (854497-57-7) → (SS,2R,3S)-N-tert-butanesulfinyl-O-[(tert-butyloxy)carbonyl]-3-(2-phenylethyl)isoserine benzyl ester

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

DOI:10.1021/jo052298n

Reference yield:

vinyl magnesium bromide (1826-67-1) + 2-Methyl-propane-2-sulfinic acid [3-phenyl-prop-(E)-ylidene]-amide (854497-57-7) → (S)-N-(5-hydroxy-1-phenylhept-6-en-3-yl)-2-methylpropane-2-sulfinamide + (S)-N-(5-hydroxy-1-phenylhept-6-en-3-yl)-2-methylpropane-2-sulfinamide

Guidance literature:

With oxygen; In tetrahydrofuran; dichloromethane; at -78 ℃; for 0.25h; under 760.051 Torr; Overall yield = 64 percent; Overall yield = 99 mg; diastereoselective reaction;

DOI:10.1002/anie.202109566

upstream raw materials:

3-phenyl-propionaldehyde

(S)-2-methylpropane-2-sulfinamide

Downstream raw materials:

(S)-5-phenylpent-1-en-3-amine

N-(1-phenethyl-allyl)-butyramide

N-(1-oxiranyl-3-phenyl-propyl)-butyramide

N-(1-oxiranyl-3-phenyl-propyl)-3-phenyl-propionamide