(S)-4-(2-benzyloxy-ethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(S)-4-(2-benzyloxy-ethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester
CAS No.:1205643-02-2
Molecular Formula:C₁₉H₂₉NO₄
Molecular Weight:335.444
Hs Code.:

Synonyms:(S)-4-(2-benzyloxy-ethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

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Chemical Property of (S)-4-(2-benzyloxy-ethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

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Technology Process of (S)-4-(2-benzyloxy-ethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

There total 1 articles about (S)-4-(2-benzyloxy-ethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 100-39-0
benzyl bromide

: 147959-18-0
(4S)-2,2-dimethyl-4-(2-hydroxyethyl)oxazolidine-3-carboxylic acid tert-butyl ester

: 1205643-02-2
(S)-4-(2-benzyloxy-ethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: (4S)-2,2-dimethyl-4-(2-hydroxyethyl)oxazolidine-3-carboxylic acid tert-butyl ester; With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.0833333h;

benzyl bromide; In tetrahydrofuran; mineral oil; for 16h;

With ammonium chloride; In tetrahydrofuran; water; mineral oil;

Reference yield:

: 1205643-02-2
(S)-4-(2-benzyloxy-ethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: (S)-2-amino-4-(benzyloxy)butan-1-ol

Guidance literature:: With hydrogenchloride; water; at 20 ℃; for 48h;
DOI:10.1016/j.bmc.2012.08.007

Reference yield:

: 1205643-02-2
(S)-4-(2-benzyloxy-ethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: C₆₃H₁₂₀N₂O₁₂Si₃

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; hydrogenchloride / 48 h / 20 °C

2.1: sodium tris(acetoxy)borohydride / chloroform / 4 h / 20 °C

3.1: sodium tris(acetoxy)borohydride / chloroform; water / 1 h / 20 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran; ethanol / 6 h / 20 °C

5.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 2 h / 20 °C

5.2: 0.5 h / Reflux

With hydrogenchloride; lithium hydroxide monohydrate; 2,4,6-trichlorobenzoyl chloride; water; sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; ethanol; chloroform; water;
DOI:10.1016/j.bmc.2012.08.007