BenzaMide, 2-aMino-N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy-

Base Information

Chemical Name:BenzaMide, 2-aMino-N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy-
CAS No.:849668-91-3
Molecular Formula:C₂₈H₃₃N₃O₅
Molecular Weight:491.587
Hs Code.:
Mol file:849668-91-3.mol

Synonyms:2-amino-N-{4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-4,5-dimethoxybenzamide

Suppliers and Price of BenzaMide, 2-aMino-N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Amino-N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-4,5-dimethoxybenzamide
250mg
$ 1040.00

Medical Isotopes, Inc.
2-Amino-N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-4,5-dimethoxybenzamide
250 mg
$ 2050.00

Total 2 raw suppliers

Chemical Property of BenzaMide, 2-aMino-N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy-

Chemical Property:

Melting Point:85-90°C
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

>98% ^*data from raw suppliers

2-Amino-N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-4,5-dimethoxybenzamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 2-Amino-N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-4,5-dimethoxybenzamide is an intermediate in the synthesis of Tariquidar (T007600), a P-glycoprotein drug efflux pump inhibitor that is potentially used in cancer patients.

Technology Process of BenzaMide, 2-aMino-N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy-

There total 7 articles about BenzaMide, 2-aMino-N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1024592-54-8
N-{4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-4,5-dimethoxy-2-nitro-benzamide

: 849668-91-3
2-amino-N-{4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-4,5-dimethoxybenzamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; dichloromethane; for 12h; under 760.051 Torr;

Reference yield:

: 4998-07-6
4,5-dimethoxy-2-nitro-benzoic acid

: 849668-91-3
2-amino-N-{4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-4,5-dimethoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 83 °C

2: sodium hydrogencarbonate / dichloromethane / 5 h / 0 - 20 °C

3: palladium 10% on activated carbon; ammonium formate; hydrogen / methanol / 4 h / Reflux

With thionyl chloride; palladium 10% on activated carbon; hydrogen; ammonium formate; sodium hydrogencarbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2015.06.049

Reference yield:

: 29568-78-3
4,5-dimethoxy-2-nitrobenzoyl chloride

: 849668-91-3
2-amino-N-{4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-4,5-dimethoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dichloromethane / 5 h / 0 - 20 °C

2: palladium 10% on activated carbon; ammonium formate; hydrogen / methanol / 4 h / Reflux

With palladium 10% on activated carbon; hydrogen; ammonium formate; sodium hydrogencarbonate; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2015.06.049