BenzaMide, N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy-2-nitro-

Base Information

Chemical Name:BenzaMide, N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy-2-nitro-
CAS No.:1024592-54-8
Molecular Formula:C₂₈H₃₁N₃O₇
Molecular Weight:521.57
Hs Code.:
Mol file:1024592-54-8.mol

Synonyms:N-{4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-4,5-dimethoxy-2-nitro-benzamide

Suppliers and Price of BenzaMide, N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy-2-nitro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-dimethoxy-2-nitrobenzamide
100mg
$ 495.00

TRC
N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-dimethoxy-2-nitrobenzamide
25mg
$ 165.00

Medical Isotopes, Inc.
N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-dimethoxy-2-nitrobenzamide
250 mg
$ 1375.00

Total 1 raw suppliers

Chemical Property of BenzaMide, N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy-2-nitro-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-dimethoxy-2-nitrobenzamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-dimethoxy-2-nitrobenzamide is an intermediate in the synthesis of Tariquidar (T007600), a P-glycoprotein drug efflux pump inhibitor that is potentially used in cancer patients.

Technology Process of BenzaMide, N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy-2-nitro-

There total 6 articles about BenzaMide, N-[4-[2-(3,4-dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-diMethoxy-2-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 29568-78-3
4,5-dimethoxy-2-nitrobenzoyl chloride

: 82925-02-8
4-<2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl>benzenamine

: 1024592-54-8
N-{4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-4,5-dimethoxy-2-nitro-benzamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 48h;
DOI:10.1016/j.bmc.2009.01.072

Reference yield:

: 4998-07-6
4,5-dimethoxy-2-nitro-benzoic acid

: 82925-02-8
4-<2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolyl)ethyl>benzenamine

: 1024592-54-8
N-{4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-4,5-dimethoxy-2-nitro-benzamide

Guidance literature:: With thionyl chloride; triethylamine; In tetrahydrofuran;

Reference yield:

: 4998-07-6
4,5-dimethoxy-2-nitro-benzoic acid

: 1024592-54-8
N-{4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl}-4,5-dimethoxy-2-nitro-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 83 °C

2: sodium hydrogencarbonate / dichloromethane / 5 h / 0 - 20 °C

With thionyl chloride; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2015.06.049