Technology Process of (E)-4-(3,5-dihydroxystyryl)phenyl pivalate
There total 9 articles about (E)-4-(3,5-dihydroxystyryl)phenyl pivalate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dimethylsulfide; boron trifluoride diethyl etherate;
In
dichloromethane;
for 20h;
Inert atmosphere;
DOI:10.1016/j.bmcl.2013.03.046
- Guidance literature:
-
(E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol;
With
sodium hydride;
In
dimethyl sulfoxide;
at 65 ℃;
for 0.333333h;
pivalic anhydride;
In
dimethyl sulfoxide;
at 65 ℃;
for 1h;
DOI:10.1016/j.tetlet.2013.12.019
- Guidance literature:
-
Multi-step reaction with 7 steps
1: potassium carbonate
2: sodium hydroxide / ethanol
3: thionyl chloride / toluene
4: 1,3-bis-(1-adamantyl)imidazolinium tetrafluoroborate; palladium diacetate; N-ethylmorpholine; / para-xylene / 3 h / 115 - 120 °C / Inert atmosphere
5: potassium hydroxide / ethanol / 2 h / 20 °C
6: pyridine / 2 h / 0 - 20 °C
7: dimethylsulfide; boron trifluoride diethyl etherate / dichloromethane / 20 h / Inert atmosphere
With
N-ethylmorpholine;; pyridine; 1,3-bis-(1-adamantyl)imidazolinium tetrafluoroborate; thionyl chloride; dimethylsulfide; boron trifluoride diethyl etherate; palladium diacetate; potassium carbonate; potassium hydroxide; sodium hydroxide;
In
ethanol; dichloromethane; para-xylene; toluene;
4: |Heck Reaction;
DOI:10.1016/j.bmcl.2013.03.046
