(Z)-1(S)-{4-[4-methyl-(1-methylethyl)pentylidene]-3-oxo-(2-oxolan-1(S)-yl)}-2-(phenylmethoxy)ethyl nonanoate

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Chemical Name:(Z)-1(S)-{4-[4-methyl-(1-methylethyl)pentylidene]-3-oxo-(2-oxolan-1(S)-yl)}-2-(phenylmethoxy)ethyl nonanoate
CAS No.:300809-92-1
Molecular Formula:C₃₁H₄₈O₅
Molecular Weight:500.719
Hs Code.:

Synonyms:(Z)-1(S)-{4-[4-methyl-(1-methylethyl)pentylidene]-3-oxo-(2-oxolan-1(S)-yl)}-2-(phenylmethoxy)ethyl nonanoate

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Chemical Property of (Z)-1(S)-{4-[4-methyl-(1-methylethyl)pentylidene]-3-oxo-(2-oxolan-1(S)-yl)}-2-(phenylmethoxy)ethyl nonanoate

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Technology Process of (Z)-1(S)-{4-[4-methyl-(1-methylethyl)pentylidene]-3-oxo-(2-oxolan-1(S)-yl)}-2-(phenylmethoxy)ethyl nonanoate

There total 7 articles about (Z)-1(S)-{4-[4-methyl-(1-methylethyl)pentylidene]-3-oxo-(2-oxolan-1(S)-yl)}-2-(phenylmethoxy)ethyl nonanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 764-85-2
Nonanoyl chloride

: 300809-85-2
(Z)-5(S)-[1(S)-hydroxy-2-(phenylmethoxy)ethyl]-3-[4-methyl-3-(methylethyl)pentylidene]oxolan-2-one

: 300809-92-1
(Z)-1(S)-{4-[4-methyl-(1-methylethyl)pentylidene]-3-oxo-(2-oxolan-1(S)-yl)}-2-(phenylmethoxy)ethyl nonanoate

Guidance literature:: With pyridine; dmap; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 261356-87-0
4-methyl-3-(1-methylethyl)pentanal

: 300809-92-1
(Z)-1(S)-{4-[4-methyl-(1-methylethyl)pentylidene]-3-oxo-(2-oxolan-1(S)-yl)}-2-(phenylmethoxy)ethyl nonanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran; heptane; ethylbenzene / 2 h / -78 °C

1.2: tetrahydrofuran; heptane; ethylbenzene / 4 h / -78 °C

2.1: Et₃N / CH₂Cl₂ / 2.5 h / 0 - 20 °C

3.1: 32 percent / DBU / CH₂Cl₂ / 20 °C

4.1: 94 percent / n-Bu₄NF / tetrahydrofuran / 0.67 h / 0 °C

5.1: 94 percent / pyridine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; dmap; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene;

Reference yield:

: 184873-70-9
(5S)-5-[(1S)-2-benzyloxy-1-hydroxyethyl]tetrahydrofuran-2-one

: 300809-92-1
(Z)-1(S)-{4-[4-methyl-(1-methylethyl)pentylidene]-3-oxo-(2-oxolan-1(S)-yl)}-2-(phenylmethoxy)ethyl nonanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 73 percent / imidazole / dimethylformamide / 17 h / 0 - 20 °C

2.1: LDA / tetrahydrofuran; heptane; ethylbenzene / 2 h / -78 °C

2.2: tetrahydrofuran; heptane; ethylbenzene / 4 h / -78 °C

3.1: Et₃N / CH₂Cl₂ / 2.5 h / 0 - 20 °C

4.1: 32 percent / DBU / CH₂Cl₂ / 20 °C

5.1: 94 percent / n-Bu₄NF / tetrahydrofuran / 0.67 h / 0 °C

6.1: 94 percent / pyridine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; 1H-imidazole; dmap; tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; N,N-dimethyl-formamide;