(+/-)-cis-methyl {2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate

Base Information

• Chemical Name: (+/-)-cis-methyl {2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate
• CAS No.: 1263282-26-3
• Molecular Formula: C₁₅H₁₈F₃NO₂
• Molecular Weight: 301.309
• Mol file: 1263282-26-3.mol

Synonyms:(+/-)-cis-methyl {2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate

Chemical Property of (+/-)-cis-methyl {2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-cis-methyl {2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate

There total 1 articles about (+/-)-cis-methyl {2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl {2-[4-(trifluoromethyl)phenyl]-4-pyridinyl}acetate (884600-79-7) → (+/-)-cis-methyl {2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate (1263282-26-3)

Guidance literature:

With hydrogenchloride; platinum(IV) oxide; hydrogen; In 1,4-dioxane; methanol; at 50 ℃; for 3h; under 2585.81 Torr;

DOI:10.1016/j.bmcl.2009.08.072

Reference yield: 35.0%

(+/-)-cis-methyl {2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate (1263282-26-3) → (+)-methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate (884602-78-2)

Guidance literature:

(+/-)-cis-methyl {2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate; With (S)-Mandelic acid; In isopropyl alcohol; at 20 ℃; for 17h;

With (R)-Mandelic Acid; In isopropyl alcohol; at 10 - 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2009.08.072

Reference yield: 25.0%

3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde (870837-18-6) + (+/-)-cis-methyl {2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate (1263282-26-3) + 3-methyl-but-1-yne (598-23-2) → methyl 2-(1-(1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methylpent-2-yn-1-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetate (1404070-17-2)

Guidance literature:

With copper(I) bromide; In toluene; at 90 ℃; for 24h; Inert atmosphere; Glovebox; Molecular sieve;

DOI:10.1016/j.bmc.2012.08.034 DOI:10.1016/j.bmc.2012.08.034

upstream raw materials:

methyl {2-[4-(trifluoromethyl)phenyl]-4-pyridinyl}acetate

Downstream raw materials:

(+)-methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate

C₂₁H₂₂F₃NO₂

C₂₆H₃₄F₃NO₂Si

C₁₉H₂₈F₃NO₂Si