2',2''-di-O-benzoyl-4'',6''-O-cyclohexylidene-3'-O-methylsulfonyl-4'-O-tetrahydropyranyl-tetra-N-ethoxycarbonylkanamycin A

Base Information

Chemical Name:2',2''-di-O-benzoyl-4'',6''-O-cyclohexylidene-3'-O-methylsulfonyl-4'-O-tetrahydropyranyl-tetra-N-ethoxycarbonylkanamycin A
CAS No.:81154-97-4
Molecular Formula:C₅₆H₇₈N₄O₂₄S
Molecular Weight:1223.31
Hs Code.:

Synonyms:2',2''-di-O-benzoyl-4'',6''-O-cyclohexylidene-3'-O-methylsulfonyl-4'-O-tetrahydropyranyl-tetra-N-ethoxycarbonylkanamycin A

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Chemical Property of 2',2''-di-O-benzoyl-4'',6''-O-cyclohexylidene-3'-O-methylsulfonyl-4'-O-tetrahydropyranyl-tetra-N-ethoxycarbonylkanamycin A

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Technology Process of 2',2''-di-O-benzoyl-4'',6''-O-cyclohexylidene-3'-O-methylsulfonyl-4'-O-tetrahydropyranyl-tetra-N-ethoxycarbonylkanamycin A

There total 9 articles about 2',2''-di-O-benzoyl-4'',6''-O-cyclohexylidene-3'-O-methylsulfonyl-4'-O-tetrahydropyranyl-tetra-N-ethoxycarbonylkanamycin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 124-63-0
methanesulfonyl chloride

: 81155-02-4
2',2''-di-O-benzoyl-4'',6''-O-cyclohexylidene-4'-O-tetrahydropyranyl-tetra-N-ethoxycarbonylkanamycin A

: 81154-97-4
2',2''-di-O-benzoyl-4'',6''-O-cyclohexylidene-3'-O-methylsulfonyl-4'-O-tetrahydropyranyl-tetra-N-ethoxycarbonylkanamycin A

Guidance literature:: With pyridine; at 50 ℃; for 1h;
DOI:10.1248/cpb.29.3469

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 81154-97-4
2',2''-di-O-benzoyl-4'',6''-O-cyclohexylidene-3'-O-methylsulfonyl-4'-O-tetrahydropyranyl-tetra-N-ethoxycarbonylkanamycin A

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / p-toluenesulfonic acid hydrate / dimethylformamide / 2 h / Ambient temperature

2: 54 percent / sodium methoxide / methanol / 1 h / Ambient temperature

3: 68 percent / pyridine / 5 °C

4: 60 percent / pyridine / 1 h / 50 °C

With pyridine; sodium methylate; toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.29.3469

Reference yield:

: 28910-12-5
tetra-N-ethoxycarbonylkanamycin A

: 81154-97-4
2',2''-di-O-benzoyl-4'',6''-O-cyclohexylidene-3'-O-methylsulfonyl-4'-O-tetrahydropyranyl-tetra-N-ethoxycarbonylkanamycin A

Guidance literature:: Multi-step reaction with 6 steps

1: p-toluenesulfonic acid hydrate / dimethylformamide / Ambient temperature

2: pyridine / 5 °C

3: 75 percent / p-toluenesulfonic acid hydrate / dimethylformamide / 2 h / Ambient temperature

4: 54 percent / sodium methoxide / methanol / 1 h / Ambient temperature

5: 68 percent / pyridine / 5 °C

6: 60 percent / pyridine / 1 h / 50 °C

With pyridine; sodium methylate; toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.29.3469