alcohol-N-[5-(6-cyano-5-hydroxy-3-oxo-hex-1-enyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide

Base Information

Chemical Name:alcohol-N-[5-(6-cyano-5-hydroxy-3-oxo-hex-1-enyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide
CAS No.:708268-64-8
Molecular Formula:C₂₂H₂₅FN₄O₄S
Molecular Weight:460.529
Hs Code.:

Synonyms:alcohol-N-[5-(6-cyano-5-hydroxy-3-oxo-hex-1-enyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of alcohol-N-[5-(6-cyano-5-hydroxy-3-oxo-hex-1-enyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide

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Technology Process of alcohol-N-[5-(6-cyano-5-hydroxy-3-oxo-hex-1-enyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide

There total 1 articles about alcohol-N-[5-(6-cyano-5-hydroxy-3-oxo-hex-1-enyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[5-[-(tert-butyl-dimethyl-silanyloxy)-6-cyano-3-oxo-hex-1-enyl]-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide

: 708268-64-8
alcohol-N-[5-(6-cyano-5-hydroxy-3-oxo-hex-1-enyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide

Guidance literature:: With methanesulfonic acid; In methanol; water; at 10 - 20 ℃; for 24h;

Reference yield:

: 708268-64-8
alcohol-N-[5-(6-cyano-5-hydroxy-3-oxo-hex-1-enyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide

: 708268-65-9
N-(5-((3S,5S,E)-6-cyano-3,5-dihydroxyhex-1-en-1-yl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide

Guidance literature:: alcohol-N-[5-(6-cyano-5-hydroxy-3-oxo-hex-1-enyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide; With diethyl methoxy borane; In tetrahydrofuran; methanol; at -78 - -76 ℃; for 0.5h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at -78 - 25 ℃; for 3.75h;

With acetic acid; In tetrahydrofuran; methanol; for 0.166667h;