N-(5-((3S,5S,E)-6-cyano-3,5-dihydroxyhex-1-en-1-yl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide

Base Information

Chemical Name:N-(5-((3S,5S,E)-6-cyano-3,5-dihydroxyhex-1-en-1-yl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
CAS No.:708268-65-9
Molecular Formula:C₂₂H₂₇FN₄O₄S
Molecular Weight:462.545
Hs Code.:

Synonyms:N-(5-((3S,5S,E)-6-cyano-3,5-dihydroxyhex-1-en-1-yl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide

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Chemical Property of N-(5-((3S,5S,E)-6-cyano-3,5-dihydroxyhex-1-en-1-yl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide

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Technology Process of N-(5-((3S,5S,E)-6-cyano-3,5-dihydroxyhex-1-en-1-yl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide

There total 5 articles about N-(5-((3S,5S,E)-6-cyano-3,5-dihydroxyhex-1-en-1-yl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: N-(5-((E)-2-((4S,6S)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide

: 708268-65-9
N-(5-((3S,5S,E)-6-cyano-3,5-dihydroxyhex-1-en-1-yl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide

Guidance literature:: With hydrogenchloride; water; In acetonitrile; at 20 ℃; for 3h; Darkness;

Reference yield:

: 503610-43-3
Rosuvastatin lactone

: 708268-65-9
N-(5-((3S,5S,E)-6-cyano-3,5-dihydroxyhex-1-en-1-yl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia / methanol / 16 h / 20 °C / Darkness

2: toluene-4-sulfonic acid / acetone / 2 h / Darkness; Cooling with ice

3: N,N-dimethyl-formamide; triethylamine; trichlorophosphate / ethyl acetate / 0.92 h / 0 °C / Darkness

4: water; hydrogenchloride / acetonitrile / 3 h / 20 °C / Darkness

With hydrogenchloride; ammonia; water; toluene-4-sulfonic acid; triethylamine; N,N-dimethyl-formamide; trichlorophosphate; In methanol; ethyl acetate; acetone; acetonitrile;

Reference yield:

: 708268-64-8
alcohol-N-[5-(6-cyano-5-hydroxy-3-oxo-hex-1-enyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide

: 708268-65-9
N-(5-((3S,5S,E)-6-cyano-3,5-dihydroxyhex-1-en-1-yl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide

Guidance literature:: alcohol-N-[5-(6-cyano-5-hydroxy-3-oxo-hex-1-enyl)-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide; With diethyl methoxy borane; In tetrahydrofuran; methanol; at -78 - -76 ℃; for 0.5h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at -78 - 25 ℃; for 3.75h;

With acetic acid; In tetrahydrofuran; methanol; for 0.166667h;