tert-butyl (3-((tert-butyldimethylsilyl)oxy)propyl)(1-cyanocyclohexyl)carbamate

Base Information

• Chemical Name: tert-butyl (3-((tert-butyldimethylsilyl)oxy)propyl)(1-cyanocyclohexyl)carbamate
• CAS No.: 1430413-27-6
• Molecular Formula: C₂₁H₄₀N₂O₃Si
• Molecular Weight: 396.646
• Mol file: 1430413-27-6.mol

Synonyms:tert-butyl (3-((tert-butyldimethylsilyl)oxy)propyl)(1-cyanocyclohexyl)carbamate

Chemical Property of tert-butyl (3-((tert-butyldimethylsilyl)oxy)propyl)(1-cyanocyclohexyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (3-((tert-butyldimethylsilyl)oxy)propyl)(1-cyanocyclohexyl)carbamate

There total 1 articles about tert-butyl (3-((tert-butyldimethylsilyl)oxy)propyl)(1-cyanocyclohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1,5-dibromo-pentane (111-24-0) + C16H32N2O3Si (1236062-60-4) → tert-butyl (3-((tert-butyldimethylsilyl)oxy)propyl)(1-cyanocyclohexyl)carbamate (1430413-27-6)

Guidance literature:

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide; In tetrahydrofuran; at -40 - 0 ℃; Inert atmosphere;

DOI:10.1021/ol400788q

Reference yield: 86.0%

tert-butyl (3-((tert-butyldimethylsilyl)oxy)propyl)(1-cyanocyclohexyl)carbamate (1430413-27-6) → tert-butyl (1-cyanocyclohexyl)(3-hydroxypropyl)carbamate (1430413-58-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

DOI:10.1021/ol400788q

Reference yield:

tert-butyl (3-((tert-butyldimethylsilyl)oxy)propyl)(1-cyanocyclohexyl)carbamate (1430413-27-6) → tert-butyl (1-cyanocyclohexyl)(3-((diethoxyphosphoryl)oxy)propyl)carbamate (1430413-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C / Inert atmosphere

2: 1-methyl-1H-imidazole / tetrahydrofuran / 0 °C / Inert atmosphere

With 1-methyl-1H-imidazole; tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1021/ol400788q

upstream raw materials:

1,5-dibromo-pentane

C₁₆H₃₂N₂O₃Si

Downstream raw materials:

tert-butyl (1-cyanocyclohexyl)(3-hydroxypropyl)carbamate

tert-butyl (1-cyanocyclohexyl)(3-((diethoxyphosphoryl)oxy)propyl)carbamate