8-benzyl-3-formyl-1-methyl-1,6,7,8-tetrahydro-5-oxa-1,8-diaza-cyclopenta[b]naphthalene-2,6-dicarboxylic acid diethyl ester

Base Information

Chemical Name:8-benzyl-3-formyl-1-methyl-1,6,7,8-tetrahydro-5-oxa-1,8-diaza-cyclopenta[b]naphthalene-2,6-dicarboxylic acid diethyl ester
CAS No.:497945-81-0
Molecular Formula:C₂₅H₂₆N₂O₆
Molecular Weight:450.491
Hs Code.:

8-benzyl-3-formyl-1-methyl-1,6,7,8-tetrahydro-5-oxa-1,8-diaza-cyclopenta[<i>b</i>]naphthalene-2,6-dicarboxylic acid diethyl ester

Synonyms:8-benzyl-3-formyl-1-methyl-1,6,7,8-tetrahydro-5-oxa-1,8-diaza-cyclopenta[b]naphthalene-2,6-dicarboxylic acid diethyl ester

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Chemical Property of 8-benzyl-3-formyl-1-methyl-1,6,7,8-tetrahydro-5-oxa-1,8-diaza-cyclopenta[b]naphthalene-2,6-dicarboxylic acid diethyl ester

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Technology Process of 8-benzyl-3-formyl-1-methyl-1,6,7,8-tetrahydro-5-oxa-1,8-diaza-cyclopenta[b]naphthalene-2,6-dicarboxylic acid diethyl ester

There total 1 articles about 8-benzyl-3-formyl-1-methyl-1,6,7,8-tetrahydro-5-oxa-1,8-diaza-cyclopenta[b]naphthalene-2,6-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 4885-02-3
Dichloromethyl methyl ether

: 462117-33-5
diethyl 4-benzyl-6-methyl-2,3,4,6-tetrahydro[1,4]oxazino[2,3-f]indole-2,7-dicarboxylate

: 8-benzyl-9-formyl-1-methyl-1,6,7,8-tetrahydro-5-oxa-1,8-diaza-cyclopenta[b]naphthalene-2,6-dicarboxylic acid diethyl ester

: 497945-81-0
8-benzyl-3-formyl-1-methyl-1,6,7,8-tetrahydro-5-oxa-1,8-diaza-cyclopenta[b]naphthalene-2,6-dicarboxylic acid diethyl ester

Guidance literature:: diethyl 4-benzyl-6-methyl-2,3,4,6-tetrahydro[1,4]oxazino[2,3-f]indole-2,7-dicarboxylate; With aluminium trichloride; In dichloromethane; at 0 ℃; for 0.05h;

Dichloromethyl methyl ether; In dichloromethane; at 0 ℃; for 1h;

Reference yield: 85.0%

: 75-52-5
nitromethane

: 497945-81-0
8-benzyl-3-formyl-1-methyl-1,6,7,8-tetrahydro-5-oxa-1,8-diaza-cyclopenta[b]naphthalene-2,6-dicarboxylic acid diethyl ester

: 497945-86-5
diethyl 4-benzyl-6-methyl-8-[(E)-nitroethenyl]-2,3,4,6-tetrahydro[1,4]oxazino[2,3-f]indole-2,7-dicarboxylate

Guidance literature:: With ammonium acetate; for 2h; Heating;

Reference yield:

: 497945-81-0
8-benzyl-3-formyl-1-methyl-1,6,7,8-tetrahydro-5-oxa-1,8-diaza-cyclopenta[b]naphthalene-2,6-dicarboxylic acid diethyl ester

: 9-benzyl-11-methyl-1-oxo-1,2,3,4,7,8,9,11-octahydro-6-oxa-2,9,11-triaza-benzo[b]fluorene-7-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / NH₄OAc / 2 h / Heating

2: 74 percent / NaBH₄; silica gel / CHCl₃; propan-2-ol / 4 h / 20 °C

3: H₂ / Raney Ni / dimethylformamide / 28 h / 20 °C / 760 Torr

4: DBU / dimethylformamide / 9 h / 20 °C

With sodium tetrahydroborate; ammonium acetate; hydrogen; silica gel; 1,8-diazabicyclo[5.4.0]undec-7-ene; nickel; In chloroform; N,N-dimethyl-formamide; isopropyl alcohol;