N-(4-(3-cyanophenyl)-5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-1,3-thiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl] acetamide

Base Information

Chemical Name:N-(4-(3-cyanophenyl)-5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-1,3-thiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl] acetamide
CAS No.:1361413-43-5
Molecular Formula:C₂₉H₂₅N₃O₅S₂
Molecular Weight:559.667
Hs Code.:

Synonyms:N-(4-(3-cyanophenyl)-5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-1,3-thiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl] acetamide

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Chemical Property of N-(4-(3-cyanophenyl)-5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-1,3-thiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl] acetamide

Chemical Property:

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Technology Process of N-(4-(3-cyanophenyl)-5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-1,3-thiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl] acetamide

There total 10 articles about N-(4-(3-cyanophenyl)-5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-1,3-thiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl] acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₂₇N₃O₆S₂

: 1361413-43-5
N-(4-(3-cyanophenyl)-5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-1,3-thiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl] acetamide

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: ethyl 2-(4-(ethylthio)phenyl)acetate

: 1361413-43-5
N-(4-(3-cyanophenyl)-5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-1,3-thiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl] acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

2.1: sodium hydroxide; water / ethanol / 20 °C

2.2: pH 1

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 72 h / 20 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 20 °C

With lithium hydroxide monohydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 103-45-7
acetic acid phenethyl ester

: 1361413-43-5
N-(4-(3-cyanophenyl)-5-{[4-(2-hydroxyethyl)phenyl]carbonyl}-1,3-thiazol-2-yl)-2-[4-(ethylsulfonyl)phenyl] acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / dichloromethane / 0 °C

1.2: 1.5 h / 0 °C

2.1: bromine / diethyl ether / 1.5 h / 0 - 20 °C

3.1: N,N-dimethyl-formamide / 0.5 h / 85 °C / Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 72 h / 20 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 20 °C

With aluminum (III) chloride; lithium hydroxide monohydrate; water; bromine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;