Technology Process of 6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-phenyl-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
There total 11 articles about 6-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-1-methyl-4-oxo-5-phenyl-3-(2,2,2-trifluoroethoxy)-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 48h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: toluene-4-sulfonic acid / cyclohexane / 2 h / Reflux
2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 7 h / 20 °C
3: triethylamine / tetrahydrofuran / 4 h / 20 °C
4: ethanol / 3 h / 50 °C
5: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 1 h / Reflux
6: trichlorophosphate / acetonitrile / 2 h / Reflux
7: triethylamine / ethanol / 40 h / Reflux
8: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
9: sodium hydroxide; water / ethanol / 1 h / 60 °C
10: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 48 h / 20 °C
With
water; hydrogen; benzotriazol-1-ol; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; trichlorophosphate;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; cyclohexane; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 7 h / 20 °C
2: triethylamine / tetrahydrofuran / 4 h / 20 °C
3: ethanol / 3 h / 50 °C
4: 2,3-dicyano-5,6-dichloro-p-benzoquinone / toluene / 1 h / Reflux
5: trichlorophosphate / acetonitrile / 2 h / Reflux
6: triethylamine / ethanol / 40 h / Reflux
7: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
8: sodium hydroxide; water / ethanol / 1 h / 60 °C
9: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 48 h / 20 °C
With
water; hydrogen; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; trichlorophosphate;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile;
