tert-butyl 5-((5S,8R,11R)-8,11-dibenzyl-5-isopropyl-1-(2-isopropylthiazol-4-yl)-2-methyl-3,6,13-trioxo-14-oxa-2,4,7,12-tetraazapentadecan-15-yl)-1H-imidazole-1-carboxylate

Base Information

Chemical Name:tert-butyl 5-((5S,8R,11R)-8,11-dibenzyl-5-isopropyl-1-(2-isopropylthiazol-4-yl)-2-methyl-3,6,13-trioxo-14-oxa-2,4,7,12-tetraazapentadecan-15-yl)-1H-imidazole-1-carboxylate
CAS No.:1383570-60-2
Molecular Formula:C₄₂H₅₇N₇O₆S
Molecular Weight:788.024
Hs Code.:

tert-butyl 5-((5S,8R,11R)-8,11-dibenzyl-5-isopropyl-1-(2-isopropylthiazol-4-yl)-2-methyl-3,6,13-trioxo-14-oxa-2,4,7,12-tetraazapentadecan-15-yl)-1H-imidazole-1-carboxylate

Synonyms:tert-butyl 5-((5S,8R,11R)-8,11-dibenzyl-5-isopropyl-1-(2-isopropylthiazol-4-yl)-2-methyl-3,6,13-trioxo-14-oxa-2,4,7,12-tetraazapentadecan-15-yl)-1H-imidazole-1-carboxylate

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Chemical Property of tert-butyl 5-((5S,8R,11R)-8,11-dibenzyl-5-isopropyl-1-(2-isopropylthiazol-4-yl)-2-methyl-3,6,13-trioxo-14-oxa-2,4,7,12-tetraazapentadecan-15-yl)-1H-imidazole-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 5-((5S,8R,11R)-8,11-dibenzyl-5-isopropyl-1-(2-isopropylthiazol-4-yl)-2-methyl-3,6,13-trioxo-14-oxa-2,4,7,12-tetraazapentadecan-15-yl)-1H-imidazole-1-carboxylate

There total 6 articles about tert-butyl 5-((5S,8R,11R)-8,11-dibenzyl-5-isopropyl-1-(2-isopropylthiazol-4-yl)-2-methyl-3,6,13-trioxo-14-oxa-2,4,7,12-tetraazapentadecan-15-yl)-1H-imidazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl 5-(hydroxymethyl)-1H-imidazole-1-carboxylate

: 1383570-60-2
tert-butyl 5-((5S,8R,11R)-8,11-dibenzyl-5-isopropyl-1-(2-isopropylthiazol-4-yl)-2-methyl-3,6,13-trioxo-14-oxa-2,4,7,12-tetraazapentadecan-15-yl)-1H-imidazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 16 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h

With triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1021/jm400288z

Reference yield:

: (2R,5R)-1,6-diphenylhexane-2,5-diamine hydrochloride

: 1383570-60-2
tert-butyl 5-((5S,8R,11R)-8,11-dibenzyl-5-isopropyl-1-(2-isopropylthiazol-4-yl)-2-methyl-3,6,13-trioxo-14-oxa-2,4,7,12-tetraazapentadecan-15-yl)-1H-imidazole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / methanol / 16 h

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 16 h

3: hydrogenchloride / methanol; dichloromethane; 1,4-dioxane / 12 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm400288z

Reference yield:

: 1383570-15-7
tert-butyl [(2R,5R)-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-yl]carbamate

: 1383570-60-2
tert-butyl 5-((5S,8R,11R)-8,11-dibenzyl-5-isopropyl-1-(2-isopropylthiazol-4-yl)-2-methyl-3,6,13-trioxo-14-oxa-2,4,7,12-tetraazapentadecan-15-yl)-1H-imidazole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol; dichloromethane; 1,4-dioxane / 12 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/jm400288z