benzyl 4-{6-[(acetylamino)methyl]-3-(3,4-dimethoxybenzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl}piperidine-1-carboxylate

Base Information

Chemical Name:benzyl 4-{6-[(acetylamino)methyl]-3-(3,4-dimethoxybenzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl}piperidine-1-carboxylate
CAS No.:1140590-97-1
Molecular Formula:C₃₃H₃₆N₄O₇
Molecular Weight:600.671
Hs Code.:

Synonyms:benzyl 4-{6-[(acetylamino)methyl]-3-(3,4-dimethoxybenzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl}piperidine-1-carboxylate

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Chemical Property of benzyl 4-{6-[(acetylamino)methyl]-3-(3,4-dimethoxybenzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl}piperidine-1-carboxylate

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Technology Process of benzyl 4-{6-[(acetylamino)methyl]-3-(3,4-dimethoxybenzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl}piperidine-1-carboxylate

There total 8 articles about benzyl 4-{6-[(acetylamino)methyl]-3-(3,4-dimethoxybenzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1140590-96-0
benzyl 4-[6-(aminomethyl)-3-(3,4-dimethoxybenzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carboxylate

: 108-24-7
acetic anhydride

: 1140590-97-1
benzyl 4-{6-[(acetylamino)methyl]-3-(3,4-dimethoxybenzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl}piperidine-1-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1140590-96-0
benzyl 4-[6-(aminomethyl)-3-(3,4-dimethoxybenzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carboxylate

: 1140590-97-1
benzyl 4-{6-[(acetylamino)methyl]-3-(3,4-dimethoxybenzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl}piperidine-1-carboxylate

Guidance literature:: With acetic anhydride; triethylamine; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

Reference yield:

: 161292-82-6
5-((tert-butoxycarbonylamino)-methyl)-2-nitro-benzoic acid methyl ester

: 1140590-97-1
benzyl 4-{6-[(acetylamino)methyl]-3-(3,4-dimethoxybenzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium formate / palladium 10% on activated carbon / ethanol / 0.08 h / 120 °C / Microwave irradiation

2.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 69 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 96 h / 20 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 16 h / 20 - 100 °C / Microwave irradiation

4.2: 0.5 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / 20 °C

With water; ammonium formate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane;