N-(2-Cyano-4,5-dimethoxy-phenyl)-4-(1-hydroxy-pentyl)-piperidine-1-carboximidothioic acid methyl ester

Base Information

Chemical Name:N-(2-Cyano-4,5-dimethoxy-phenyl)-4-(1-hydroxy-pentyl)-piperidine-1-carboximidothioic acid methyl ester
CAS No.:86543-30-8
Molecular Formula:C₂₁H₃₁N₃O₃S
Molecular Weight:405.561
Hs Code.:

Synonyms:N-(2-Cyano-4,5-dimethoxy-phenyl)-4-(1-hydroxy-pentyl)-piperidine-1-carboximidothioic acid methyl ester

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Chemical Property of N-(2-Cyano-4,5-dimethoxy-phenyl)-4-(1-hydroxy-pentyl)-piperidine-1-carboximidothioic acid methyl ester

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Technology Process of N-(2-Cyano-4,5-dimethoxy-phenyl)-4-(1-hydroxy-pentyl)-piperidine-1-carboximidothioic acid methyl ester

There total 6 articles about N-(2-Cyano-4,5-dimethoxy-phenyl)-4-(1-hydroxy-pentyl)-piperidine-1-carboximidothioic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 86543-23-9
4-(1-Hydroxy-pentyl)-piperidine-1-carbothioic acid (2-cyano-4,5-dimethoxy-phenyl)-amide

: 74-88-4
methyl iodide

: 86543-30-8
N-(2-Cyano-4,5-dimethoxy-phenyl)-4-(1-hydroxy-pentyl)-piperidine-1-carboximidothioic acid methyl ester

Guidance literature:: With calcium oxide; In chloroform; Heating;
DOI:10.1021/jm00364a014

Reference yield:

: 62718-31-4
1-benzylpiperidine-4-carbonitrile

: 86543-30-8
N-(2-Cyano-4,5-dimethoxy-phenyl)-4-(1-hydroxy-pentyl)-piperidine-1-carboximidothioic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / a) reflux, 3 h, b) RT, overnight

2: 1 N aq. HCl, H₂ / 10percent Pd/C / methanol / 760 Torr / Ambient temperature

3: sodium borohydride / methanol / 2 h / Ambient temperature

4: 55 percent / dimethylformamide / 0 °C

5: 83 percent / calcium oxide / CHCl₃ / Heating

With hydrogenchloride; sodium tetrahydroborate; hydrogen; calcium oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a014

Reference yield:

: 62992-68-1
1-benzyl-piperidine-4-carboxylic acid amide

: 86543-30-8
N-(2-Cyano-4,5-dimethoxy-phenyl)-4-(1-hydroxy-pentyl)-piperidine-1-carboximidothioic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 73 percent / thionyl chloride / 3 h / Heating

2: tetrahydrofuran / a) reflux, 3 h, b) RT, overnight

3: 1 N aq. HCl, H₂ / 10percent Pd/C / methanol / 760 Torr / Ambient temperature

4: sodium borohydride / methanol / 2 h / Ambient temperature

5: 55 percent / dimethylformamide / 0 °C

6: 83 percent / calcium oxide / CHCl₃ / Heating

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; hydrogen; calcium oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00364a014