(4R,5R)-5-((E)-3-chloroprop-1-enyl)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazole

Base Information

Chemical Name:(4R,5R)-5-((E)-3-chloroprop-1-enyl)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazole
CAS No.:951385-87-8
Molecular Formula:C₂₀H₂₀ClNO₂
Molecular Weight:341.837
Hs Code.:

Synonyms:(4R,5R)-5-((E)-3-chloroprop-1-enyl)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazole

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Chemical Property of (4R,5R)-5-((E)-3-chloroprop-1-enyl)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazole

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Technology Process of (4R,5R)-5-((E)-3-chloroprop-1-enyl)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazole

There total 9 articles about (4R,5R)-5-((E)-3-chloroprop-1-enyl)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 951385-90-3
N-((2R,3S,E)-6-chloro-3-hydroxy-1-(4-methoxyphenyl)hex-4-en-2-yl)benzamide

: 951385-87-8
(4R,5R)-5-((E)-3-chloroprop-1-enyl)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazole

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; toluene; at 20 ℃; for 0.25h;
DOI:10.1021/ol701519b

Reference yield:

: 951385-94-7
C₂₀H₂₁NO₃

: 951385-87-8
(4R,5R)-5-((E)-3-chloroprop-1-enyl)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazole

Guidance literature:: With dmap; p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/ol701519b

Reference yield:

: C₁₈H₁₇NO₃

: 951385-87-8
(4R,5R)-5-((E)-3-chloroprop-1-enyl)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiCl; diisopropylethylamine / acetonitrile / 1 h

1.2: 2.08 g / acetonitrile / 2 h

2.1: 99 percent / i-Bu₂AlH / tetrahydrofuran / 2 h / -78 °C

3.1: 1.41 g / p-toluenesulfonyl chloride; N,N-dimethylaminopyridine / CH₂Cl₂ / 24 h / 20 °C

With dmap; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; p-toluenesulfonyl chloride; lithium chloride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ol701519b