methyl (E)-3-((4R,5R)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazol-5-yl)acrylate

Base Information

Chemical Name:methyl (E)-3-((4R,5R)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazol-5-yl)acrylate
CAS No.:951385-86-7
Molecular Formula:C₂₁H₂₁NO₄
Molecular Weight:351.402
Hs Code.:

Synonyms:methyl (E)-3-((4R,5R)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazol-5-yl)acrylate

Suppliers and Price of methyl (E)-3-((4R,5R)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazol-5-yl)acrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (E)-3-((4R,5R)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazol-5-yl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (E)-3-((4R,5R)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazol-5-yl)acrylate

There total 3 articles about methyl (E)-3-((4R,5R)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazol-5-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 951385-85-6
(4R,5R)-4-(4-methoxybenzyl)-2-phenyl-5-vinyl-4,5-dihydrooxazole

: 951385-86-7
methyl (E)-3-((4R,5R)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazol-5-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ozone / methanol / -78 °C

2.1: LiCl; diisopropylethylamine / acetonitrile / 1 h

2.2: 2.08 g / acetonitrile / 2 h

With ozone; N-ethyl-N,N-diisopropylamine; lithium chloride; In methanol; acetonitrile;
DOI:10.1021/ol701519b

Reference yield:

: (R)-4-benzamido-5-(4-methoxyphenyl)pent-1-en-3-yl acetate

: 951385-86-7
methyl (E)-3-((4R,5R)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazol-5-yl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 75 percent / Pd(PPh₃)4; K₂CO₃ / acetonitrile / 24 h / Heating

2.1: ozone / methanol / -78 °C

3.1: LiCl; diisopropylethylamine / acetonitrile / 1 h

3.2: 2.08 g / acetonitrile / 2 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; ozone; N-ethyl-N,N-diisopropylamine; lithium chloride; In methanol; acetonitrile;
DOI:10.1021/ol701519b

Reference yield:

: C₁₈H₁₇NO₃

: 5927-18-4
trimethyl phosphonoacetate

: 951385-86-7
methyl (E)-3-((4R,5R)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazol-5-yl)acrylate

: methyl (Z)-3-((4R,5R)-4-(4-methoxybenzyl)-2-phenyl-4,5-dihydrooxazol-5-yl)acrylate

Guidance literature:: trimethyl phosphonoacetate; With N-ethyl-N,N-diisopropylamine; lithium chloride; In acetonitrile; for 1h;

C₁₈H₁₇NO₃; In acetonitrile; for 2h; Further stages.;
DOI:10.1021/ol701519b