N-(2-benzyloxethyl){2,3,4,9-tetrahydrospiro[1H-carbazole-1,2'[1,3]dithiolane]-2-yl}-2-acetamide

Base Information

Chemical Name:N-(2-benzyloxethyl){2,3,4,9-tetrahydrospiro[1H-carbazole-1,2'[1,3]dithiolane]-2-yl}-2-acetamide
CAS No.:1260175-30-1
Molecular Formula:C₂₅H₂₈N₂O₂S₂
Molecular Weight:452.642
Hs Code.:

Synonyms:N-(2-benzyloxethyl){2,3,4,9-tetrahydrospiro[1H-carbazole-1,2'[1,3]dithiolane]-2-yl}-2-acetamide

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Chemical Property of N-(2-benzyloxethyl){2,3,4,9-tetrahydrospiro[1H-carbazole-1,2'[1,3]dithiolane]-2-yl}-2-acetamide

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Technology Process of N-(2-benzyloxethyl){2,3,4,9-tetrahydrospiro[1H-carbazole-1,2'[1,3]dithiolane]-2-yl}-2-acetamide

There total 2 articles about N-(2-benzyloxethyl){2,3,4,9-tetrahydrospiro[1H-carbazole-1,2'[1,3]dithiolane]-2-yl}-2-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1260175-29-8
{2,3,4,9-tetrahydrospiro[1H-carbazole-1,2'[1,3]dithiolane]-2-yl}-2-acetic acid

: 38336-04-8
O-benzylethanolamine

: 1260175-30-1
N-(2-benzyloxethyl){2,3,4,9-tetrahydrospiro[1H-carbazole-1,2'[1,3]dithiolane]-2-yl}-2-acetamide

Guidance literature:: {2,3,4,9-tetrahydrospiro[1H-carbazole-1,2'[1,3]dithiolane]-2-yl}-2-acetic acid; With chloroformic acid ethyl ester; triethylamine; In chloroform; at -5 ℃; for 3h;

O-benzylethanolamine; In chloroform; at -5 ℃; for 3h;
DOI:10.1021/jo1021663

Reference yield:

: 1000808-62-7
ethyl{2,3,4,9-tetrahydrospiro[1H-carbazole-1,2'[1,3]dithiolane]-2-yl}-2-acetate

: 1260175-30-1
N-(2-benzyloxethyl){2,3,4,9-tetrahydrospiro[1H-carbazole-1,2'[1,3]dithiolane]-2-yl}-2-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; potassium hydroxide / tetrahydrofuran; methanol / 5 h / 20 °C

2.1: chloroformic acid ethyl ester; triethylamine / chloroform / 3 h / -5 °C

2.2: 3 h / -5 °C

With water; chloroformic acid ethyl ester; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/jo1021663

Reference yield: 70.0%

: 1260175-30-1
N-(2-benzyloxethyl){2,3,4,9-tetrahydrospiro[1H-carbazole-1,2'[1,3]dithiolane]-2-yl}-2-acetamide

: 2-(2-benzyloxyethyl)-6-(1,2-dithiolane-2-yl)-1,2,3,4,5,6-hexahydro-1,5-methano-1H-azocino[4,3-b]indole-3-one

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jo1021663