1-Bromcyclopentyl-p-chlorphenylketon

Base Information

• Chemical Name: 1-Bromcyclopentyl-p-chlorphenylketon
• CAS No.: 6728-56-9
• Molecular Formula: C₁₂H₁₂BrClO
• Molecular Weight: 287.584
• Mol file: 6728-56-9.mol

Synonyms:1-Bromcyclopentyl-p-chlorphenylketon

Chemical Property of 1-Bromcyclopentyl-p-chlorphenylketon

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-Bromcyclopentyl-p-chlorphenylketon

There total 3 articles about 1-Bromcyclopentyl-p-chlorphenylketon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-chlorophenyl)(cyclopentyl)methanone (2204-98-0) → 1-Bromcyclopentyl-p-chlorphenylketon (6728-56-9)

Guidance literature:

With bromine; acetic acid; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/acs.orglett.8b00409

Reference yield:

4-Cyanochlorobenzene (623-03-0) → 1-Bromcyclopentyl-p-chlorphenylketon (6728-56-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper(l) iodide / tetrahydrofuran / 20 °C / Inert atmosphere

1.2: 4 h / 20 °C / Inert atmosphere

2.1: acetic acid; bromine / dichloromethane / 0 - 20 °C

With copper(l) iodide; bromine; acetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/acs.orglett.0c01626

Reference yield:

→ 1-Bromcyclopentyl-p-chlorphenylketon (6728-56-9)

Guidance literature:

Cyclopentyl-p-chlorphenylketon, N-Bromsuccinimid;

upstream raw materials:

(4-chlorophenyl)(cyclopentyl)methanone

4-Cyanochlorobenzene