N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide

Base Information

Chemical Name:N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide
CAS No.:1293987-76-4
Molecular Formula:C₁₄H₁₂ClN₃O₂S₂
Molecular Weight:353.853
Hs Code.:

Synonyms:N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide

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Technology Process of N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide

There total 9 articles about N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1293987-57-1
N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-methanesulfonamide

: 74-88-4
methyl iodide

: 1293987-76-4
N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

Reference yield:

: 1293987-57-1
N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-methanesulfonamide

: 7646-69-7
sodium hydride

: 1293987-76-4
N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide

Guidance literature:: N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-methanesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

sodium hydride; In N,N-dimethyl-formamide; for 1h;

Reference yield:

: 16233-51-5
1H-thieno[3,2-d]pyrimidine-2,4-dione

: 1293987-76-4
N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-N-methylmethanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: bromine / acetic acid / 30 h / 110 °C

2: N,N-diethylaniline; trichlorophosphate / 5 h / 150 °C

3: sodium tetrahydroborate / ethanol; tetrahydrofuran / 1 h / 20 °C

4: chloranil / benzene / 3 h / Reflux

5: sodium carbonate; tert-butyl XPhos / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 6 h / 90 °C / Inert atmosphere

6: triethylamine / tetrahydrofuran / 2 h

7: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

With sodium tetrahydroborate; bromine; chloranil; sodium hydride; sodium carbonate; triethylamine; N,N-diethylaniline; tert-butyl XPhos; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; acetic acid; N,N-dimethyl-formamide; benzene; 5: Suzuki Coupling;