(R)-2,2'-((5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)azanediyl)diacetic acid

Base Information

Chemical Name:(R)-2,2'-((5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)azanediyl)diacetic acid
CAS No.:1445984-57-5
Molecular Formula:C₃₁H₃₈Cl₂N₄O₅S
Molecular Weight:649.639
Hs Code.:

(R)-2,2'-((5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)azanediyl)diacetic acid

Synonyms:(R)-2,2'-((5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)azanediyl)diacetic acid

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Chemical Property of (R)-2,2'-((5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)azanediyl)diacetic acid

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Technology Process of (R)-2,2'-((5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)azanediyl)diacetic acid

There total 12 articles about (R)-2,2'-((5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)azanediyl)diacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: methyl 2-[[5-(2,5-dichloro-4-[[(4R)-4-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]-1,3-thiazolidin-3-yl]methyl]phenyl)pentyl](2-methoxy-2-oxoethyl)amino]acetate

: 1445984-57-5
(R)-2,2'-((5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)azanediyl)diacetic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In 1,4-dioxane; methanol; at 80 ℃; for 1h;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: 1445985-47-6
tert-butyl (4R)-4-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]-1,3-thiazolidine-3-carboxylate

: 1445984-57-5
(R)-2,2'-((5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)azanediyl)diacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / water; 1,4-dioxane / 1 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide

3: hydrogenchloride / water; 1,4-dioxane / 1 h

4: triethylamine / acetonitrile / 50 °C

5: lithium hydroxide monohydrate; water / methanol; 1,4-dioxane / 1 h / 80 °C

With hydrogenchloride; lithium hydroxide monohydrate; water; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: 1445985-48-7
1-cyclopropyl-4-[[(4R)-1,3-thiazolidin-4-yl]carbonyl]-1,2,3,4-tetrahydroquinoxaline

: 1445984-57-5
(R)-2,2'-((5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentyl)azanediyl)diacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: hydrogenchloride / water; 1,4-dioxane / 1 h

3: triethylamine / acetonitrile / 50 °C

4: lithium hydroxide monohydrate; water / methanol; 1,4-dioxane / 1 h / 80 °C

With hydrogenchloride; lithium hydroxide monohydrate; water; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00308