2,5-Dichloro-4-hydroxybenzaldehyde

Base Information

Chemical Name:2,5-Dichloro-4-hydroxybenzaldehyde
CAS No.:27164-10-9
Molecular Formula:C7H4Cl2O2
Molecular Weight:191.014
Hs Code.:
DSSTox Substance ID:DTXSID501295966
Mol file:27164-10-9.mol

Synonyms:2,5-dichloro-4-hydroxybenzaldehyde;27164-10-9;Benzaldehyde, 2,5-dichloro-4-hydroxy;SCHEMBL3377931;TQP0770;DTXSID501295966;MFCD06656940;AKOS017515403;AS-48045;CS-0308414;EN300-119344;F17590;2,5-Dichloro-4-hydroxybenzaldehyde, AldrichCPR;Z1255427969

Suppliers and Price of 2,5-Dichloro-4-hydroxybenzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,5-dichloro-4-hydroxybenzaldehyde
10mg
$ 45.00

AK Scientific
2,5-Dichloro-4-hydroxybenzaldehyde
250mg
$ 345.00

AK Scientific
2,5-Dichloro-4-hydroxybenzaldehyde
100mg
$ 271.00

Total 5 raw suppliers

Chemical Property of 2,5-Dichloro-4-hydroxybenzaldehyde

Chemical Property:

Vapor Pressure:0.0035mmHg at 25°C
PSA：37.30000
LogP:2.51150
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:189.9588348
Heavy Atom Count:11
Complexity:151

Purity/Quality:

99% ^*data from raw suppliers

2,5-dichloro-4-hydroxybenzaldehyde ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=CC(=C1Cl)O)Cl)C=O
Uses 2,5-Dichloro-4-hydroxybenzaldehyde can be used in the design and preparation of gut-restricted thiazolidine agonists of G protein-coupled bile acid receptor 1 (GPBAR1, TGR5). It can be useful in the synthesis of new mescaline analogs as potential psychotropic agents as well as in the discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-?associated antigen-?1? (LFA-1) /intercellular adhesion molecule-?1 (ICAM-1).

Technology Process of 2,5-Dichloro-4-hydroxybenzaldehyde

There total 3 articles about 2,5-Dichloro-4-hydroxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 381229-74-9
4-methoxy-3,6-dichlorobenzaldehyde

: 27164-10-9
2,5-dichloro-4-hydroxybenzaldehyde

Guidance literature:: With lithium chloride; In N,N-dimethyl-formamide; at 140 ℃; Inert atmosphere;

Reference yield: 8.0%

: 67-66-3,8013-54-5
chloroform

: 583-78-8
2,5-dichlorophenol

: 27164-10-9
2,5-dichloro-4-hydroxybenzaldehyde

Guidance literature:: With calcium hydroxide; sodium carbonate; In water; for 2h; Heating;
DOI:10.1021/je00031a039

Reference yield:

: 1984-58-3
2,5-dichloroanisole

: 27164-10-9
2,5-dichloro-4-hydroxybenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / TiCl₄ / CH₂Cl₂ / 2 h / Heating

2: BBr₃ / CH₂Cl₂ / 1 h / 0 °C

With boron tribromide; titanium tetrachloride; In dichloromethane;
DOI:10.1021/jm0103108