1-[5-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-2-nitrophenyl]ethoxycarbonyl L-leucyl-L-leucine methyl ester

Base Information

Chemical Name:1-[5-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-2-nitrophenyl]ethoxycarbonyl L-leucyl-L-leucine methyl ester
CAS No.:418759-64-5
Molecular Formula:C₃₆H₅₁N₃O₁₇
Molecular Weight:797.811
Hs Code.:

Synonyms:1-[5-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-2-nitrophenyl]ethoxycarbonyl L-leucyl-L-leucine methyl ester

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Chemical Property of 1-[5-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-2-nitrophenyl]ethoxycarbonyl L-leucyl-L-leucine methyl ester

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Technology Process of 1-[5-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-2-nitrophenyl]ethoxycarbonyl L-leucyl-L-leucine methyl ester

There total 5 articles about 1-[5-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-2-nitrophenyl]ethoxycarbonyl L-leucyl-L-leucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: L-leucyl-L-leucine methyl ester trifluoroacetic salt

: 418759-62-3
1-[5-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-2-nitrophenyl]ethyl 4-nitrophenyl carbonate

: 418759-64-5
1-[5-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-2-nitrophenyl]ethoxycarbonyl L-leucyl-L-leucine methyl ester

Guidance literature:: With triethylamine; In 1,4-dioxane; at 20 ℃; for 72h; in dark;
DOI:10.1016/S0968-0896(01)00323-6

Reference yield:

: 121-71-1
3-Hydroxyacetophenone

: 418759-64-5
1-[5-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-2-nitrophenyl]ethoxycarbonyl L-leucyl-L-leucine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: cuprous nitrate / acetic acid; acetic anhydride

2: 92 percent / BF₃*Et₂O / CH₂Cl₂ / 13 h / 20 °C

3: 51 percent / NaBH₄ / tetrahydrofuran; ethanol / 0.5 h / 20 °C

4: 58 percent / triethylamine / CH₂Cl₂ / 17 h / 20 °C

5: 80 percent / triethylamine / dioxane / 72 h / 20 °C / in dark

With sodium tetrahydroborate; cuprous nitrate; boron trifluoride diethyl etherate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetic anhydride; acetic acid;
DOI:10.1016/S0968-0896(01)00323-6

Reference yield:

: 30879-49-3
1-(5-hydroxy-2-nitrophenyl)ethan-1-one

: 418759-64-5
1-[5-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-2-nitrophenyl]ethoxycarbonyl L-leucyl-L-leucine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / BF₃*Et₂O / CH₂Cl₂ / 13 h / 20 °C

2: 51 percent / NaBH₄ / tetrahydrofuran; ethanol / 0.5 h / 20 °C

3: 58 percent / triethylamine / CH₂Cl₂ / 17 h / 20 °C

4: 80 percent / triethylamine / dioxane / 72 h / 20 °C / in dark

With sodium tetrahydroborate; boron trifluoride diethyl etherate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/S0968-0896(01)00323-6