rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(4-hydroxyphenyl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide

Base Information

Chemical Name:rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(4-hydroxyphenyl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide
CAS No.:292144-13-9
Molecular Formula:C₂₆H₂₆ClN₃O₄S
Molecular Weight:512.029
Hs Code.:

Synonyms:rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(4-hydroxyphenyl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide

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Chemical Property of rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(4-hydroxyphenyl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide

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Technology Process of rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(4-hydroxyphenyl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide

There total 11 articles about rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(4-hydroxyphenyl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 292144-09-3
N-(4-chlorobenzyl)-2-(hydroxymethyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide

: 532-80-9,582-84-3,614-35-7,94-07-5
synephrine

: 292144-13-9
rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(4-hydroxyphenyl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide

Guidance literature:: With 2,4,6-trimethyl-pyridine; dmap; methanesulfonyl chloride; In N,N-dimethyl-formamide;

Reference yield:

: 292143-52-3,863101-95-5
N-(4-chlorobenzyl)-4-hydroxy-2-iodothieno[2,3-b]pyridine-5-carboxamide

: 292144-13-9
rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(4-hydroxyphenyl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / methanol; water; N,N-dimethyl-formamide

2: LiAlH₄ / tetrahydrofuran

3: potassium carbonate / N,N-dimethyl-formamide

4: dmap; 2,4,6-trimethyl-pyridine; methanesulfonyl chloride / N,N-dimethyl-formamide

With 2,4,6-trimethyl-pyridine; hydrogenchloride; dmap; LiAlH₄; potassium carbonate; methanesulfonyl chloride; triethylamine; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 4-hydroxy-2-iodothieno[2,3-b]pyridine-5-carboxylic acid

: 292144-13-9
rac-N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(4-hydroxyphenyl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide

2: hydrogenchloride; triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / methanol; water; N,N-dimethyl-formamide

3: LiAlH₄ / tetrahydrofuran

4: potassium carbonate / N,N-dimethyl-formamide

5: dmap; 2,4,6-trimethyl-pyridine; methanesulfonyl chloride / N,N-dimethyl-formamide

With 2,4,6-trimethyl-pyridine; hydrogenchloride; dmap; LiAlH₄; potassium carbonate; methanesulfonyl chloride; triethylamine; 1,1'-carbonyldiimidazole; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;