6-Bromo-4-chloro-2-(4-chlorophenyl)quinazoline

Base Information

• Chemical Name: 6-Bromo-4-chloro-2-(4-chlorophenyl)quinazoline
• CAS No.: 885277-66-7
• Molecular Formula: C14H7 Br Cl2 N2
• Molecular Weight: 354.03
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID10696256
• Wikidata: Q82625781
• Mol file: 885277-66-7.mol

Synonyms:885277-66-7;6-Bromo-4-chloro-2-(4-chlorophenyl)quinazoline;6-BROMO-4-CHLORO-2-(4-CHLORO-PHENYL)-QUINAZOLINE;DTXSID10696256;MFCD04115254;AKOS012806452;AB19803;CS-0340088;FT-0758054

Chemical Property of 6-Bromo-4-chloro-2-(4-chlorophenyl)quinazoline

Chemical Property:

• PSA: 25.78000
• LogP: 5.36610
• Storage Temp.: 2-8°C
• XLogP3: 5.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 351.91697
• Heavy Atom Count: 19
• Complexity: 310

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromo-4-chloro-2-(4-chlorophenyl)quinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=NC3=C(C=C(C=C3)Br)C(=N2)Cl)Cl

Technology Process of 6-Bromo-4-chloro-2-(4-chlorophenyl)quinazoline

There total 3 articles about 6-Bromo-4-chloro-2-(4-chlorophenyl)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

6-bromo-2-(4-chlorophenyl)quinazolin-4(3H)-one (115221-15-3) → 6-bromo-4-chloro-2-(4-chlorophenyl)quinazoline (885277-66-7)

Guidance literature:

With triethylamine; trichlorophosphate; for 5h; Reflux;

DOI:10.3390/ph10040087

Reference yield:

5-bromoanthranilamide (16313-66-9) → 6-bromo-4-chloro-2-(4-chlorophenyl)quinazoline (885277-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine / ethanol / 8 h / Reflux

2: triethylamine; trichlorophosphate / 5 h / Reflux

With iodine; triethylamine; trichlorophosphate; In ethanol;

DOI:10.3390/ph10040087

Reference yield:

4-chlorobenzaldehyde (104-88-1) → 6-bromo-4-chloro-2-(4-chlorophenyl)quinazoline (885277-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine / ethanol / 8 h / Reflux

2: triethylamine; trichlorophosphate / 5 h / Reflux

With iodine; triethylamine; trichlorophosphate; In ethanol;

DOI:10.3390/ph10040087

upstream raw materials:

6-bromo-2-(4-chlorophenyl)quinazolin-4(3H)-one

5-bromoanthranilamide

4-chlorobenzaldehyde

Downstream raw materials:

C₁₉H₁₈BrClN₄

C₂₀H₁₉BrClN₃

C₂₅H₂₁BrClN₃

C₂₄H₂₀BrClN₄

Refernces

• 1、 Alafeefy, Ahmed M.,Kadi, Adnan A.,Al-Deeb, Omar A.,El-Tahir, Kamal E.H.,Al-Jaber, Nabila A.. "Synthesis, analgesic and anti-inflammatory evaluation of some novel quinazoline derivatives". scheme or table. p. 4947 - 4952. Retrieved 2010/11/20.