Technology Process of (2R,3R,4S,5R,6E)-1-[(tert-butyldiphenylsilyl)oxy]-5-methoxy-2,4-dimethyl-7-phenyl-6-hepten-3-ol
There total 8 articles about (2R,3R,4S,5R,6E)-1-[(tert-butyldiphenylsilyl)oxy]-5-methoxy-2,4-dimethyl-7-phenyl-6-hepten-3-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1H-imidazole; dmap;
In
dichloromethane;
at -5 ℃;
for 1h;
Inert atmosphere;
DOI:10.1002/ejoc.201101635
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / -78 °C / Inert atmosphere
2.1: benzene / 12 h / 80 °C / Inert atmosphere
3.1: silver(l) oxide / 36 h / 50 °C / Darkness; Inert atmosphere
4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.5 h / 0 °C / Inert atmosphere
5.1: L-(+)-diisopropyl tartrate; titanium(IV)isopropoxide / dichloromethane / 0.5 h / -23 °C / Molecular sieve; Inert atmosphere
5.2: 18 h / -23 °C / Inert atmosphere
6.1: diethyl ether / 1.5 h / -45 °C / Inert atmosphere
7.1: 1H-imidazole; dmap / dichloromethane / 1 h / -5 °C / Inert atmosphere
With
1H-imidazole; dmap; L-(+)-diisopropyl tartrate; titanium(IV)isopropoxide; diisobutylaluminium hydride; silver(l) oxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; toluene; benzene;
2.1: Wittig reaction / 5.1: Katsuki-Sharpless epoxidation / 5.2: Katsuki-Sharpless epoxidation;
DOI:10.1002/ejoc.201101635
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: silver(l) oxide / 36 h / 50 °C / Darkness; Inert atmosphere
2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.5 h / 0 °C / Inert atmosphere
3.1: L-(+)-diisopropyl tartrate; titanium(IV)isopropoxide / dichloromethane / 0.5 h / -23 °C / Molecular sieve; Inert atmosphere
3.2: 18 h / -23 °C / Inert atmosphere
4.1: diethyl ether / 1.5 h / -45 °C / Inert atmosphere
5.1: 1H-imidazole; dmap / dichloromethane / 1 h / -5 °C / Inert atmosphere
With
1H-imidazole; dmap; L-(+)-diisopropyl tartrate; titanium(IV)isopropoxide; diisobutylaluminium hydride; silver(l) oxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; toluene;
3.1: Katsuki-Sharpless epoxidation / 3.2: Katsuki-Sharpless epoxidation;
DOI:10.1002/ejoc.201101635
