2-[(2'-methylcarboxyethyl-4',5'-dimethoxy)phenyl]-5,6-dimethoxyindole

Base Information

• Chemical Name: 2-[(2'-methylcarboxyethyl-4',5'-dimethoxy)phenyl]-5,6-dimethoxyindole
• CAS No.: 278800-99-0
• Molecular Formula: C₂₁H₂₃NO₆
• Molecular Weight: 385.417
• Mol file: 278800-99-0.mol

Synonyms:2-[(2'-methylcarboxyethyl-4',5'-dimethoxy)phenyl]-5,6-dimethoxyindole

Chemical Property of 2-[(2'-methylcarboxyethyl-4',5'-dimethoxy)phenyl]-5,6-dimethoxyindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2'-methylcarboxyethyl-4',5'-dimethoxy)phenyl]-5,6-dimethoxyindole

There total 2 articles about 2-[(2'-methylcarboxyethyl-4',5'-dimethoxy)phenyl]-5,6-dimethoxyindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

methyl 2-[2-(4,5-dimethoxy-2-nitrophenyl)acetyl]-4,5-dimethoxyphenylacetate (154953-90-9) → 2-[(2'-methylcarboxyethyl-4',5'-dimethoxy)phenyl]-5,6-dimethoxyindole (278800-99-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; isopropyl alcohol; for 1h; under 912 Torr;

DOI:10.3987/com-99-8838

Reference yield:

2-<(3',4'-dimethoxy-6'-nitrophenylacetyl)-4,5-dimethoxy>phenylacetic acid (83573-15-3) → 2-[(2'-methylcarboxyethyl-4',5'-dimethoxy)phenyl]-5,6-dimethoxyindole (278800-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / concd. sulfuric acid / 2 h / Heating

2: 71 percent / hydrogen / 10 percent Pd/C / methanol; propan-2-ol / 1 h / 912 Torr

With sulfuric acid; hydrogen; palladium on activated charcoal; In methanol; isopropyl alcohol; 1: Esterification / 2: Reduction;

DOI:10.3987/com-99-8838

Reference yield:

2-[(2'-methylcarboxyethyl-4',5'-dimethoxy)phenyl]-5,6-dimethoxyindole (278800-99-0) → O-methylcryptaustoline iodide (58939-41-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / p-toluenesulfonic acid / CH₂Cl₂ / 3.5 h / 20 °C

2: zinc powder; concd. hydrochloric acid / acetic acid; H₂O / 1.5 h / Heating

3: 55 percent / methanol / 48 h / 20 °C

With hydrogenchloride; toluene-4-sulfonic acid; zinc; In methanol; dichloromethane; water; acetic acid; 1: Cyclization / 2: Reduction / 3: Methylation;

DOI:10.3987/com-99-8838

upstream raw materials:

methyl 2-[2-(4,5-dimethoxy-2-nitrophenyl)acetyl]-4,5-dimethoxyphenylacetate

2-<(3',4'-dimethoxy-6'-nitrophenylacetyl)-4,5-dimethoxy>phenylacetic acid

Downstream raw materials:

O-methylcryptaustoline iodide