3-((4-(6-chloro-2-(3-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole

Base Information

Chemical Name:3-((4-(6-chloro-2-(3-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole
CAS No.:1402709-74-3
Molecular Formula:C₂₆H₃₁ClN₈O
Molecular Weight:507.038
Hs Code.:

Synonyms:3-((4-(6-chloro-2-(3-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole

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Chemical Property of 3-((4-(6-chloro-2-(3-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole

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Technology Process of 3-((4-(6-chloro-2-(3-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole

There total 3 articles about 3-((4-(6-chloro-2-(3-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 942949-34-0
5-chloro-4-[4-(5-methyl-isoxazol-3-ylmethyl)piperazin-1-yl]-3-nitro-pyridin-2-ylamine

: 628325-62-2
3-(4-methylpiperazin-1-yl)benzaldehyde

: 1402709-74-3
3-((4-(6-chloro-2-(3-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole

Guidance literature:: With sodium dithionite; In ethanol; water; at 80 ℃; for 24h;

Reference yield:

: 75148-49-1
3-bromobenzaldehyde diethylacetal

: 1402709-74-3
3-((4-(6-chloro-2-(3-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 18 h / 100 °C / Inert atmosphere

1.2: 2.5 h

2.1: sodium dithionite / ethanol; water / 24 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium dithionite; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In ethanol; water; toluene;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1402709-74-3
3-((4-(6-chloro-2-(3-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)methyl)-5-methylisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 18 h / 100 °C / Inert atmosphere

1.2: 2.5 h

2.1: sodium dithionite / ethanol; water / 24 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium dithionite; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In ethanol; water; toluene;