6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino]nicotinic acid

Base Information

Chemical Name:6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino]nicotinic acid
CAS No.:1337469-50-7
Molecular Formula:C₂₉H₃₄N₂O₃
Molecular Weight:458.601
Hs Code.:

Synonyms:6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino]nicotinic acid

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Chemical Property of 6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino]nicotinic acid

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Technology Process of 6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino]nicotinic acid

There total 3 articles about 6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino]nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1337469-42-7
C₃₀H₃₆N₂O₃

: 1337469-50-7
6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino]nicotinic acid

Guidance literature:: C₃₀H₃₆N₂O₃; With sodium hydroxide; In tetrahydrofuran; methanol; at 60 ℃; for 1h;

With hydrogenchloride; In methanol; water;
DOI:10.1021/ml200197e

Reference yield:

: 1055233-46-9
methyl 6-[N-ethyl-N-(3-isobutoxy-4-isopropylphenyl)amino]nicotinate

: 1337469-50-7
6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino]nicotinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: iodine; silver sulfate / methanol / 11 h / 20 °C

2: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine / acetonitrile / 72 h / 110 °C / Inert atmosphere

3: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 60 °C

With iodine; palladium diacetate; silver sulfate; triethylamine; tris-(o-tolyl)phosphine; sodium hydroxide; In tetrahydrofuran; methanol; acetonitrile; 2: Heck reaction;
DOI:10.1021/ml200197e

Reference yield:

: 1337469-43-8
methyl 6-[N-ethyl-N-(2-iodo-5-isobutoxy-4-isopropylphenyl)amino]nicotinate

: 1337469-50-7
6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino]nicotinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine / acetonitrile / 72 h / 110 °C / Inert atmosphere

2: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 60 °C

With palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; sodium hydroxide; In tetrahydrofuran; methanol; acetonitrile; 1: Heck reaction;
DOI:10.1021/ml200197e