methyl (1R,2S,4R)-{{[(tert-butyl)diphenylsilyl]oxy}methyl}-4-[(methylsulfonyl)oxy]cyclopentaneacetate

Base Information

Chemical Name:methyl (1R,2S,4R)-{{[(tert-butyl)diphenylsilyl]oxy}methyl}-4-[(methylsulfonyl)oxy]cyclopentaneacetate
CAS No.:802912-09-0
Molecular Formula:C₂₆H₃₆O₆SSi
Molecular Weight:504.72
Hs Code.:

Synonyms:methyl (1R,2S,4R)-{{[(tert-butyl)diphenylsilyl]oxy}methyl}-4-[(methylsulfonyl)oxy]cyclopentaneacetate

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Chemical Property of methyl (1R,2S,4R)-{{[(tert-butyl)diphenylsilyl]oxy}methyl}-4-[(methylsulfonyl)oxy]cyclopentaneacetate

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Technology Process of methyl (1R,2S,4R)-{{[(tert-butyl)diphenylsilyl]oxy}methyl}-4-[(methylsulfonyl)oxy]cyclopentaneacetate

There total 6 articles about methyl (1R,2S,4R)-{{[(tert-butyl)diphenylsilyl]oxy}methyl}-4-[(methylsulfonyl)oxy]cyclopentaneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 124-63-0
methanesulfonyl chloride

: 802912-08-9
methyl (1R,2S,4R)-2-(<(tert-butyl)diphenylsilyloxy>methyl)-4-hydroxycyclopentaneacetate

: 802912-09-0
methyl (1R,2S,4R)-{{[(tert-butyl)diphenylsilyl]oxy}methyl}-4-[(methylsulfonyl)oxy]cyclopentaneacetate

Guidance literature:: With dmap; In dichloromethane; for 0.5h; cooling;
DOI:10.1002/hlca.200490202

Reference yield:

: 802912-03-4
(1R,4R,5S)-5-(hydroxymethyl)bicyclo[2.2.1]heptane-2-one

: 802912-09-0
methyl (1R,2S,4R)-{{[(tert-butyl)diphenylsilyl]oxy}methyl}-4-[(methylsulfonyl)oxy]cyclopentaneacetate

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / NaHCO₃; 3-chloroperbenzoic acid / CH₂Cl₂ / 2 h / 20 °C

2: 90 percent / HCl; water / 20 h / Heating

3: 70 percent / 1H-imidazole / dimethylformamide / 40 h / 20 °C

4: 99 percent / N,N-dimethylpyridin-4-amine / CH₂Cl₂ / 0.5 h / cooling

With 1H-imidazole; hydrogenchloride; dmap; water; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Baeyer-Villiger oxidation;
DOI:10.1002/hlca.200490202

Reference yield:

: 802912-06-7
(1R,5R,6S)-6-(hydroxymethyl)-2-oxabicyclo[3.2.1]octan-3-one

: 802912-09-0
methyl (1R,2S,4R)-{{[(tert-butyl)diphenylsilyl]oxy}methyl}-4-[(methylsulfonyl)oxy]cyclopentaneacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / HCl; water / 20 h / Heating

2: 70 percent / 1H-imidazole / dimethylformamide / 40 h / 20 °C

3: 99 percent / N,N-dimethylpyridin-4-amine / CH₂Cl₂ / 0.5 h / cooling

With 1H-imidazole; hydrogenchloride; dmap; water; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200490202