7>nordidemnin

Base Information

• Chemical Name: 7>nordidemnin
• CAS No.: 130466-66-9
• Molecular Formula: C₅₆H₈₇N₇O₁₅
• Molecular Weight: 1098.34

Synonyms:7>nordidemnin

Chemical Property of 7>nordidemnin

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Technology Process of 7>nordidemnin

There total 2 articles about 7>nordidemnin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

(5S,8R,10S,14S,15R,18S,19R,22S,24aS)-18-Amino-14-hydroxy-5-isobutyl-10,15-diisopropyl-22-(4-methoxy-benzyl)-8,19,23-trimethyl-tetradecahydro-11,20-dioxa-3a,6,16,23-tetraaza-cyclopentacyclotricosene-4,7,9,12,17,21,24-heptaone (117733-99-0) + L-lactyl-L-prolyl-N-methyl-L-leucine (130466-68-1) → 7>nordidemnin (130466-66-9)

Guidance literature:

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1021/jm00106a002

Reference yield:

L-prolyl-N-methyl-L-leucine methyl ester trifluoroacetate (117710-33-5) → 7>nordidemnin (130466-66-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 2 N NaOH / methanol / 0.5 h

2: 26 percent / (1H-1,2,3-benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), N-methylmorpholine (NMM) / CH₂Cl₂ / 3 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In methanol; dichloromethane;

DOI:10.1021/jm00106a002

Reference yield:

nordidemnin B (117710-03-9,130466-66-9) → 2-({1-[2-(4-Hydroxy-2,5-dimethyl-3-oxo-hexanoylamino)-4-methyl-pentanoyl]-pyrrolidine-2-carbonyl}-methyl-amino)-3-(4-methoxy-phenyl)-propionic acid methyl ester

Guidance literature:

With potassium hydroxide; In methanol;

DOI:10.1016/S0040-4039(00)99400-0

upstream raw materials:

(5S,8R,10S,14S,15R,18S,19R,22S,24aS)-18-Amino-14-hydroxy-5-isobutyl-10,15-diisopropyl-22-(4-methoxy-benzyl)-8,19,23-trimethyl-tetradecahydro-11,20-dioxa-3a,6,16,23-tetraaza-cyclopentacyclotricosene-4,7,9,12,17,21,24-heptaone

L-lactyl-L-prolyl-N-methyl-L-leucine

L-prolyl-N-methyl-L-leucine methyl ester trifluoroacetate

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