(Diethoxy-phosphoryl)-acetic acid (R)-5-benzyloxy-1-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-3-oxo-pentyl ester

Base Information

Chemical Name:(Diethoxy-phosphoryl)-acetic acid (R)-5-benzyloxy-1-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-3-oxo-pentyl ester
CAS No.:312326-53-7
Molecular Formula:C₃₇H₅₁O₈PSi
Molecular Weight:682.866
Hs Code.:

Synonyms:(Diethoxy-phosphoryl)-acetic acid (R)-5-benzyloxy-1-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-3-oxo-pentyl ester

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Chemical Property of (Diethoxy-phosphoryl)-acetic acid (R)-5-benzyloxy-1-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-3-oxo-pentyl ester

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Technology Process of (Diethoxy-phosphoryl)-acetic acid (R)-5-benzyloxy-1-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-3-oxo-pentyl ester

There total 9 articles about (Diethoxy-phosphoryl)-acetic acid (R)-5-benzyloxy-1-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-3-oxo-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 312326-52-6
(Diethoxy-phosphoryl)-acetic acid (1R,2R)-1-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-ylmethyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester

: 312326-53-7
(Diethoxy-phosphoryl)-acetic acid (R)-5-benzyloxy-1-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-3-oxo-pentyl ester

Guidance literature:: With silica gel; iron(III) chloride; In chloroform;
DOI:10.1016/S0040-4039(00)01337-X

Reference yield:

: 5694-95-1
2-(2-(2-hydroxyethyl)-1,3-dioxolan-2-yl)ethanol

: 312326-53-7
(Diethoxy-phosphoryl)-acetic acid (R)-5-benzyloxy-1-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-3-oxo-pentyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaH / tetrahydrofuran

1.2: 76 percent / Bu₄NI

2.1: 97 percent / Dess-Martin periodinane

3.1: 83 percent / Bu₂BOTf / CH₂Cl₂

4.1: 85 percent / LiBH₄ / tetrahydrofuran

5.1: 99 percent / imidazole / dimethylformamide

6.1: 84 percent / EDC / CH₂Cl₂

7.1: 99 percent / FeCl₃; SiO₂ / CHCl₃

With 1H-imidazole; lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; silica gel; iron(III) chloride; sodium hydride; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; 1.1: Metallation / 2.1: Oxidation / 3.1: Metallation / 4.1: Reduction / 5.1: Substitution / 6.1: Acylation / 7.1: Ring cleavage;
DOI:10.1016/S0040-4039(00)01337-X

Reference yield:

: 6506-31-6
dimethyl acetonedicarboxylate ethylene ketal

: 312326-53-7
(Diethoxy-phosphoryl)-acetic acid (R)-5-benzyloxy-1-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-3-oxo-pentyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 99 percent / LiAlH₄ / tetrahydrofuran

2.1: NaH / tetrahydrofuran

2.2: 76 percent / Bu₄NI

3.1: 97 percent / Dess-Martin periodinane

4.1: 83 percent / Bu₂BOTf / CH₂Cl₂

5.1: 85 percent / LiBH₄ / tetrahydrofuran

6.1: 99 percent / imidazole / dimethylformamide

7.1: 84 percent / EDC / CH₂Cl₂

8.1: 99 percent / FeCl₃; SiO₂ / CHCl₃

With 1H-imidazole; lithium aluminium tetrahydride; lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; silica gel; iron(III) chloride; sodium hydride; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; 1.1: Reduction / 2.1: Metallation / 3.1: Oxidation / 4.1: Metallation / 5.1: Reduction / 6.1: Substitution / 7.1: Acylation / 8.1: Ring cleavage;
DOI:10.1016/S0040-4039(00)01337-X