2,2-dimethyl-N-(2-(2-(1-methyl-1-vinyl-3-cyanopropyl)-3-pyridyl)phenyl)propanamide

Base Information

Chemical Name:2,2-dimethyl-N-(2-(2-(1-methyl-1-vinyl-3-cyanopropyl)-3-pyridyl)phenyl)propanamide
CAS No.:340699-81-2
Molecular Formula:C₂₃H₂₇N₃O
Molecular Weight:361.487
Hs Code.:

Synonyms:2,2-dimethyl-N-(2-(2-(1-methyl-1-vinyl-3-cyanopropyl)-3-pyridyl)phenyl)propanamide

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Chemical Property of 2,2-dimethyl-N-(2-(2-(1-methyl-1-vinyl-3-cyanopropyl)-3-pyridyl)phenyl)propanamide

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Technology Process of 2,2-dimethyl-N-(2-(2-(1-methyl-1-vinyl-3-cyanopropyl)-3-pyridyl)phenyl)propanamide

There total 8 articles about 2,2-dimethyl-N-(2-(2-(1-methyl-1-vinyl-3-cyanopropyl)-3-pyridyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 340699-80-1
2,2-dimethyl-N-(2-(2-(1-(1-hydroxyethyl)-1-methyl-3-cyanopropyl)-3-pyridyl)phenyl)propanamide

: 2,2-dimethyl-N-(2-(2-(1-methyl-3-cyanopropyl)-3-pyridyl)phenyl)propanamide

: 340699-81-2
2,2-dimethyl-N-(2-(2-(1-methyl-1-vinyl-3-cyanopropyl)-3-pyridyl)phenyl)propanamide

Guidance literature:: With sulfuric acid; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 220 ℃; for 1h;
DOI:10.1021/jo0014156

Reference yield:

: 1121-25-1,55780-69-3
2-methyl-3-pyridinol

: 340699-81-2
2,2-dimethyl-N-(2-(2-(1-methyl-1-vinyl-3-cyanopropyl)-3-pyridyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 73 percent / Py / 1.25 h / 20 °C

2.1: 95 percent / Pd(PPh₃)4; K₂CO₃ / toluene; ethanol / 6 h / Heating

3.1: n-BuLi / tetrahydrofuran / 1 h / -20 °C

3.2: 84 percent / tetrahydrofuran / 0.25 h / -70 °C

4.1: n-BuLi / tetrahydrofuran / -70 - 20 °C

4.2: 78 percent / tetrahydrofuran / 16 h / 20 °C

5.1: 82 percent / BnMe₃N⁺OH^- / methanol; 2-methyl-propan-2-ol / 16 h / 20 °C

6.1: 89 percent / NaBH₄ / ethanol / 4 h / 20 °C

7.1: 61 percent / H₂SO₄ / hexamethylphosphoric acid triamide / 1 h / 220 °C

With pyridine; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sulfuric acid; N-benzyl-trimethylammonium hydroxide; potassium carbonate; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; toluene; tert-butyl alcohol;
DOI:10.1021/jo0014156

Reference yield:

: 146140-95-6
2-pivaloylaminophenyl boronic acid

: 340699-81-2
2,2-dimethyl-N-(2-(2-(1-methyl-1-vinyl-3-cyanopropyl)-3-pyridyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 45 h / 20 °C

1.2: 95 percent / K₂CO₃ / Pd(PPh₃)4 / ethanol; H₂O; toluene / 3 h / 80 °C

2.1: n-BuLi / tetrahydrofuran / 1 h / -20 °C

2.2: 84 percent / tetrahydrofuran / 0.25 h / -70 °C

3.1: n-BuLi / tetrahydrofuran / -70 - 20 °C

3.2: 78 percent / tetrahydrofuran / 16 h / 20 °C

4.1: 82 percent / BnMe₃N⁺OH^- / methanol; 2-methyl-propan-2-ol / 16 h / 20 °C

5.1: 89 percent / NaBH₄ / ethanol / 4 h / 20 °C

6.1: 61 percent / H₂SO₄ / hexamethylphosphoric acid triamide / 1 h / 220 °C

With pyridine; sodium tetrahydroborate; n-butyllithium; sulfuric acid; N-benzyl-trimethylammonium hydroxide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; tert-butyl alcohol;
DOI:10.1021/jo0014156