(2S,6S)-6-(methanesulfonyloxymethyl)-4-(4-methoxybenzyl)morpholine-2-carboxylic acid 4-methoxybenzylamide

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Chemical Name:(2S,6S)-6-(methanesulfonyloxymethyl)-4-(4-methoxybenzyl)morpholine-2-carboxylic acid 4-methoxybenzylamide
CAS No.:1099828-13-3
Molecular Formula:C₂₃H₃₀N₂O₇S
Molecular Weight:478.566
Hs Code.:

Synonyms:(2S,6S)-6-(methanesulfonyloxymethyl)-4-(4-methoxybenzyl)morpholine-2-carboxylic acid 4-methoxybenzylamide

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Chemical Property of (2S,6S)-6-(methanesulfonyloxymethyl)-4-(4-methoxybenzyl)morpholine-2-carboxylic acid 4-methoxybenzylamide

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Technology Process of (2S,6S)-6-(methanesulfonyloxymethyl)-4-(4-methoxybenzyl)morpholine-2-carboxylic acid 4-methoxybenzylamide

There total 1 articles about (2S,6S)-6-(methanesulfonyloxymethyl)-4-(4-methoxybenzyl)morpholine-2-carboxylic acid 4-methoxybenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 51594-55-9,24969-06-0,13403-37-7
(R)-(-)-epichlorohydrin

: 1099828-11-1
2-hydroxy-N-(4-methoxybenzyl)-3-(4-methoxybenzylamino)propionamide

: 124-63-0
methanesulfonyl chloride

: 1099828-12-2
(2R,6S)-6-(methanesulfonyloxymethyl)-4-(4-methoxybenzyl)morpholine-2-carboxylic acid 4-methoxybenzylamide

: 1099828-13-3
(2S,6S)-6-(methanesulfonyloxymethyl)-4-(4-methoxybenzyl)morpholine-2-carboxylic acid 4-methoxybenzylamide

Guidance literature:: (R)-(-)-epichlorohydrin; 2-hydroxy-N-(4-methoxybenzyl)-3-(4-methoxybenzylamino)propionamide; With lithium perchlorate; In toluene; at 70 ℃; for 26h; Inert atmosphere;

With potassium tert-butylate; In toluene; tert-butyl alcohol; at 20 ℃; for 18h; Inert atmosphere;

methanesulfonyl chloride; With triethylamine; In toluene; tert-butyl alcohol; at 0 - 20 ℃; optical yield given as %de; regioselective reaction; Inert atmosphere;
DOI:10.1021/jo802409x

Reference yield: 92.0%

: 1099828-13-3
(2S,6S)-6-(methanesulfonyloxymethyl)-4-(4-methoxybenzyl)morpholine-2-carboxylic acid 4-methoxybenzylamide

: 1099828-14-4
(1R,5S)-3,7-bis(4-methoxybenzyl)-9-oxa-3,7-diazabicyclo[3.3.1]nonan-2-one

Guidance literature:: With potassium tert-butylate; In toluene; tert-butyl alcohol; for 19h; Inert atmosphere; Reflux;
DOI:10.1021/jo802409x