(2S,3R,4S)-2-<<(1-piperazinylcarbonyl)-L-phenylalanyl-L-histidyl>amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane bis(acetic acid) salt

Base Information

Chemical Name:(2S,3R,4S)-2-<<(1-piperazinylcarbonyl)-L-phenylalanyl-L-histidyl>amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane bis(acetic acid) salt
CAS No.:114457-21-5
Molecular Formula:2C₂H₄O₂*C₃₄H₅₃N₇O₅
Molecular Weight:759.944
Hs Code.:

Synonyms:(2S,3R,4S)-2-<<(1-piperazinylcarbonyl)-L-phenylalanyl-L-histidyl>amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane bis(acetic acid) salt

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Chemical Property of (2S,3R,4S)-2-<<(1-piperazinylcarbonyl)-L-phenylalanyl-L-histidyl>amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane bis(acetic acid) salt

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Technology Process of (2S,3R,4S)-2-<<(1-piperazinylcarbonyl)-L-phenylalanyl-L-histidyl>amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane bis(acetic acid) salt

There total 5 articles about (2S,3R,4S)-2-<<(1-piperazinylcarbonyl)-L-phenylalanyl-L-histidyl>amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane bis(acetic acid) salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 64-19-7,77671-22-8
acetic acid

: 114457-65-7
4-{(S)-1-[(S)-1-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-piperazine-1-carboxylic acid benzyl ester

: 114457-21-5
(2S,3R,4S)-2-<<(1-piperazinylcarbonyl)-L-phenylalanyl-L-histidyl>amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane bis(acetic acid) salt

Guidance literature:: With hydrogen; palladium on activated charcoal; for 3h; under 760 Torr;
DOI:10.1021/jm00120a006

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 114457-21-5
(2S,3R,4S)-2-<<(1-piperazinylcarbonyl)-L-phenylalanyl-L-histidyl>amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane bis(acetic acid) salt

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 90 - 100 °C

2: CH₂Cl₂ / 0.17 h / 0 - 5 °C

3: LiOH / dioxane; H₂O / 1 h / 0 - 5 °C

4: 52 percent / hydroxybenzotriazole, DCC / dimethylformamide / 0 deg C, 2.5 h; 25 deg C, 12 h

5: 87 percent / hydrogen / 20percent Pd/C / 3 h / 760 Torr

With lithium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00120a006

Reference yield:

: 40203-94-9
methyl (S)-2-isocyanato-3-phenylpropanoate

: 114457-21-5
(2S,3R,4S)-2-<<(1-piperazinylcarbonyl)-L-phenylalanyl-L-histidyl>amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane bis(acetic acid) salt

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 0.17 h / 0 - 5 °C

2: LiOH / dioxane; H₂O / 1 h / 0 - 5 °C

3: 52 percent / hydroxybenzotriazole, DCC / dimethylformamide / 0 deg C, 2.5 h; 25 deg C, 12 h

4: 87 percent / hydrogen / 20percent Pd/C / 3 h / 760 Torr

With lithium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00120a006