diethyl 2-(methylthio)-1-<3-(4-aminophenyl)propyl>imidazole-4,5-dicarboxylate

Base Information

• Chemical Name: diethyl 2-(methylthio)-1-<3-(4-aminophenyl)propyl>imidazole-4,5-dicarboxylate
• CAS No.: 218629-02-8
• Molecular Formula: C₁₉H₂₅N₃O₄S
• Molecular Weight: 391.491

Synonyms:diethyl 2-(methylthio)-1-<3-(4-aminophenyl)propyl>imidazole-4,5-dicarboxylate

Chemical Property of diethyl 2-(methylthio)-1-<3-(4-aminophenyl)propyl>imidazole-4,5-dicarboxylate

Chemical Property:

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Technology Process of diethyl 2-(methylthio)-1-<3-(4-aminophenyl)propyl>imidazole-4,5-dicarboxylate

There total 2 articles about diethyl 2-(methylthio)-1-<3-(4-aminophenyl)propyl>imidazole-4,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-3-(4-nitrophenyl)propane (53712-77-9) → diethyl 2-(methylthio)-1-<3-(4-aminophenyl)propyl>imidazole-4,5-dicarboxylate (218629-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃ / dimethylformamide / 2.5 h / 70 °C

2: 99 percent / H₂ / Pt/C / methanol / 2 h / 2585.74 Torr

With hydrogen; potassium carbonate; platinum on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm9803119

Reference yield:

diethyl 2-methylthio-4,5-imidazoledicarboxylate (117121-00-3) → diethyl 2-(methylthio)-1-<3-(4-aminophenyl)propyl>imidazole-4,5-dicarboxylate (218629-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃ / dimethylformamide / 2.5 h / 70 °C

2: 99 percent / H₂ / Pt/C / methanol / 2 h / 2585.74 Torr

With hydrogen; potassium carbonate; platinum on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm9803119

Reference yield: 60.0%

9-Chloroacridine (1207-69-8) + diethyl 2-(methylthio)-1-<3-(4-aminophenyl)propyl>imidazole-4,5-dicarboxylate (218629-02-8) → diethyl 1-<3-<4-(9-acridinylamino)phenyl>propyl>-2-(methylthio)imidazole-4,5-dicarboxylate

Guidance literature:

With hydrogenchloride; In methanol; a) 20 deg C, 1 h, b) reflux, 30 min;

DOI:10.1021/jm9803119

upstream raw materials:

1-bromo-3-(4-nitrophenyl)propane

diethyl 2-methylthio-4,5-imidazoledicarboxylate

Downstream raw materials:

diethyl 2-(methylthio)-1-<3-<4-<4-(4-quinolinylamino)benzamido>phenyl>propyl>imidazole-4,5-dicarboxylate

(3-{3-[4-(acridin-9-ylamino)-phenyl]-propyl}-5-hydroxymethyl-2-methylsulfanyl-3H-imidazol-4-yl)-methanol

N-{4-[3-(4,5-bis-hydroxymethyl-2-methylsulfanyl-imidazol-1-yl)-propyl]-phenyl}-4-(quinolin-4-ylamino)-benzamide

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