C₁₆H₁₇BrN₄

Base Information

• Chemical Name: C₁₆H₁₇BrN₄
• CAS No.: 1415980-85-6
• Molecular Formula: C₁₆H₁₇BrN₄
• Molecular Weight: 345.242
• Mol file: 1415980-85-6.mol

Synonyms:C₁₆H₁₇BrN₄

Chemical Property of C₁₆H₁₇BrN₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₇BrN₄

There total 3 articles about C₁₆H₁₇BrN₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-Aminopyrazine (5049-61-6) + tert-butylisonitrile (119072-55-8,7188-38-7) + 4-bromobenzenemethanol (873-75-6) → C16H17BrN4 (1415980-85-6)

Guidance literature:

4-bromobenzenemethanol; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In dimethyl sulfoxide; ethyl acetate; at 0 - 20 ℃; for 1h;

2-Aminopyrazine; In dimethyl sulfoxide; ethyl acetate; for 0.25h;

tert-butylisonitrile; In dimethyl sulfoxide; ethyl acetate; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2012.10.112

Reference yield: 72.0%

pyrimidin-4-amine (163133-86-6,163133-87-7,176772-96-6,176773-06-1,176773-07-2,176799-58-9,591-54-8) + tert-butylisonitrile (119072-55-8,7188-38-7) + 4-bromo-benzaldehyde (1122-91-4) → C16H17BrN4 (1415980-85-6)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In dichloromethane; water; at 150 ℃; for 1h; Microwave irradiation;

Reference yield: 64.1%

2-Aminopyrazine (5049-61-6) + tert-butylisonitrile (119072-55-8,7188-38-7) + 4-bromo-benzaldehyde (1122-91-4) → C16H17BrN4 (1415980-85-6)

Guidance literature:

With perchloric acid; In methanol; at 20 ℃; for 8h;

upstream raw materials:

2-Aminopyrazine

tert-butylisonitrile

4-bromobenzenemethanol

4-bromo-benzaldehyde

Downstream raw materials:

2-(4-bromophenyl)imidazo[1,2-a]pyrazin-3-amine

C₂₁H₁₇BrN₄O₂

Refernces

• 1、 -. "INHIBITORS OF TRANSCRIPTION FACTORS AND USES THEREOF". Paragraph 00334. . Retrieved 2015/02/19.
• 2、 McKeown, Michael R.,Shaw, Daniel L.,Fu, Harry,Liu, Shuai,Xu, Xiang,Marineau, Jason J.,Huang, Yibo,Zhang, Xiaofeng,Buckley, Dennis L.,Kadam, Asha,Zhang, Zijuan,Blacklow, Stephen C.,Qi, Jun,Zhang, Wei,Bradner, James E.. "Biased multicomponent reactions to develop novel bromodomain inhibitors". . p. 9019 - 9027. Retrieved 2015/03/14.