tert-butyl (2S,5S)-1-benzyl-5-((S)-1-((2-(trimethylsilyl)ethoxy)-carbonylamino)but-3-enyl)pyrrolidine-2-carboxylate

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Chemical Name:tert-butyl (2S,5S)-1-benzyl-5-((S)-1-((2-(trimethylsilyl)ethoxy)-carbonylamino)but-3-enyl)pyrrolidine-2-carboxylate
CAS No.:1235568-48-5
Molecular Formula:C₂₆H₄₂N₂O₄Si
Molecular Weight:474.716
Hs Code.:

Synonyms:tert-butyl (2S,5S)-1-benzyl-5-((S)-1-((2-(trimethylsilyl)ethoxy)-carbonylamino)but-3-enyl)pyrrolidine-2-carboxylate

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Chemical Property of tert-butyl (2S,5S)-1-benzyl-5-((S)-1-((2-(trimethylsilyl)ethoxy)-carbonylamino)but-3-enyl)pyrrolidine-2-carboxylate

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Technology Process of tert-butyl (2S,5S)-1-benzyl-5-((S)-1-((2-(trimethylsilyl)ethoxy)-carbonylamino)but-3-enyl)pyrrolidine-2-carboxylate

There total 1 articles about tert-butyl (2S,5S)-1-benzyl-5-((S)-1-((2-(trimethylsilyl)ethoxy)-carbonylamino)but-3-enyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 1235568-42-9
(S)-2-((2S,5S)-1-benzyl-5-(tert-butoxycarbonyl)pyrrolidin-2-yl)-pent-4-enoic acid

: 1235568-48-5
tert-butyl (2S,5S)-1-benzyl-5-((S)-1-((2-(trimethylsilyl)ethoxy)-carbonylamino)but-3-enyl)pyrrolidine-2-carboxylate

Guidance literature:: (S)-2-((2S,5S)-1-benzyl-5-(tert-butoxycarbonyl)pyrrolidin-2-yl)-pent-4-enoic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; at 50 - 110 ℃; for 5.5h; Inert atmosphere;

2-(Trimethylsilyl)ethanol; In toluene; at 110 ℃; for 20h; Inert atmosphere;
DOI:10.1021/jo1008433

Reference yield: 66.0%

: 1235568-48-5
tert-butyl (2S,5S)-1-benzyl-5-((S)-1-((2-(trimethylsilyl)ethoxy)-carbonylamino)but-3-enyl)pyrrolidine-2-carboxylate

: 1235568-60-1
C₂₅H₄₀N₂O₅Si

Guidance literature:: tert-butyl (2S,5S)-1-benzyl-5-((S)-1-((2-(trimethylsilyl)ethoxy)-carbonylamino)but-3-enyl)pyrrolidine-2-carboxylate; With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; tert-butyl alcohol; at 20 ℃; for 2h; Inert atmosphere;

With sodium periodate; In tetrahydrofuran; water; tert-butyl alcohol; for 15h; Inert atmosphere;
DOI:10.1021/jo1008433