(S)-2-((2S,5S)-1-benzyl-5-(tert-butoxycarbonyl)pyrrolidin-2-yl)-pent-4-enoic acid

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Chemical Name:(S)-2-((2S,5S)-1-benzyl-5-(tert-butoxycarbonyl)pyrrolidin-2-yl)-pent-4-enoic acid
CAS No.:1235568-42-9
Molecular Formula:C₂₁H₂₉NO₄
Molecular Weight:359.466
Hs Code.:

Synonyms:(S)-2-((2S,5S)-1-benzyl-5-(tert-butoxycarbonyl)pyrrolidin-2-yl)-pent-4-enoic acid

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Chemical Property of (S)-2-((2S,5S)-1-benzyl-5-(tert-butoxycarbonyl)pyrrolidin-2-yl)-pent-4-enoic acid

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Technology Process of (S)-2-((2S,5S)-1-benzyl-5-(tert-butoxycarbonyl)pyrrolidin-2-yl)-pent-4-enoic acid

There total 1 articles about (S)-2-((2S,5S)-1-benzyl-5-(tert-butoxycarbonyl)pyrrolidin-2-yl)-pent-4-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1235568-27-0
tert-butyl (2S,5S)-1-benzyl-5-((S)-1-ethoxy-1-oxopent-4-en-2-yl)pyrrolidine-2-carboxylate

: 1235568-42-9
(S)-2-((2S,5S)-1-benzyl-5-(tert-butoxycarbonyl)pyrrolidin-2-yl)-pent-4-enoic acid

Guidance literature:: tert-butyl (2S,5S)-1-benzyl-5-((S)-1-ethoxy-1-oxopent-4-en-2-yl)pyrrolidine-2-carboxylate; With tetra(n-butyl)ammonium hydroxide; sodium hydroxide; In methanol; water; at 50 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; In water; pH=3;
DOI:10.1021/jo1008433

Reference yield: 75.0%

: 115-20-8
1,1,1-trichloroethanol

: 1235568-42-9
(S)-2-((2S,5S)-1-benzyl-5-(tert-butoxycarbonyl)pyrrolidin-2-yl)-pent-4-enoic acid

: 1235568-43-0
tert-butyl (2S,5S)-1-benzyl-5-((S)-1-((2,2,2-trichloroethoxy)-carbonylamino)but-3-enyl)pyrrolidine-2-carboxylate

Guidance literature:: (S)-2-((2S,5S)-1-benzyl-5-(tert-butoxycarbonyl)pyrrolidin-2-yl)-pent-4-enoic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; at 50 - 110 ℃; for 5.5h; Inert atmosphere;

1,1,1-trichloroethanol; In toluene; at 110 ℃; for 20h; Inert atmosphere;
DOI:10.1021/jo1008433

Reference yield: 58.0%

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 1235568-42-9
(S)-2-((2S,5S)-1-benzyl-5-(tert-butoxycarbonyl)pyrrolidin-2-yl)-pent-4-enoic acid

: 1235568-48-5
tert-butyl (2S,5S)-1-benzyl-5-((S)-1-((2-(trimethylsilyl)ethoxy)-carbonylamino)but-3-enyl)pyrrolidine-2-carboxylate

Guidance literature:: (S)-2-((2S,5S)-1-benzyl-5-(tert-butoxycarbonyl)pyrrolidin-2-yl)-pent-4-enoic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; at 50 - 110 ℃; for 5.5h; Inert atmosphere;

2-(Trimethylsilyl)ethanol; In toluene; at 110 ℃; for 20h; Inert atmosphere;
DOI:10.1021/jo1008433