5-[[[1-(tert-butoxycarbonylaminomethyl)-2-ethoxycarbonyl-ethyl]benzyloxycarbonylamino]methyl]-4,5-dihydro-isoxazole-3-carboxylic acid ethyl ester

Base Information

Chemical Name:5-[[[1-(tert-butoxycarbonylaminomethyl)-2-ethoxycarbonyl-ethyl]benzyloxycarbonylamino]methyl]-4,5-dihydro-isoxazole-3-carboxylic acid ethyl ester
CAS No.:1359874-78-4
Molecular Formula:C₂₆H₃₇N₃O₉
Molecular Weight:535.594
Hs Code.:

5-[[[1-(tert-butoxycarbonylaminomethyl)-2-ethoxycarbonyl-ethyl]benzyloxycarbonylamino]methyl]-4,5-dihydro-isoxazole-3-carboxylic acid ethyl ester

Synonyms:5-[[[1-(tert-butoxycarbonylaminomethyl)-2-ethoxycarbonyl-ethyl]benzyloxycarbonylamino]methyl]-4,5-dihydro-isoxazole-3-carboxylic acid ethyl ester

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Chemical Property of 5-[[[1-(tert-butoxycarbonylaminomethyl)-2-ethoxycarbonyl-ethyl]benzyloxycarbonylamino]methyl]-4,5-dihydro-isoxazole-3-carboxylic acid ethyl ester

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Technology Process of 5-[[[1-(tert-butoxycarbonylaminomethyl)-2-ethoxycarbonyl-ethyl]benzyloxycarbonylamino]methyl]-4,5-dihydro-isoxazole-3-carboxylic acid ethyl ester

There total 5 articles about 5-[[[1-(tert-butoxycarbonylaminomethyl)-2-ethoxycarbonyl-ethyl]benzyloxycarbonylamino]methyl]-4,5-dihydro-isoxazole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1359874-77-3
(S)-3-[(N-allyl)benzyloxycarbonylamino]-4-tert-butoxycarbonylamino-butyric acid ethyl ester

: 14337-43-0
ethyl 2-chloro-2-(hydroxyimino)acetate

: 1359874-78-4
5-[[[1-(tert-butoxycarbonylaminomethyl)-2-ethoxycarbonyl-ethyl]benzyloxycarbonylamino]methyl]-4,5-dihydro-isoxazole-3-carboxylic acid ethyl ester

Guidance literature:: With sodium hydrogencarbonate; In ethyl acetate; at 20 ℃; for 12h;
DOI:10.1021/ol203433c DOI:10.1021/ol300495m

Reference yield:

: 1359874-75-1
(S)-4-azido-3-benzyloxycarbonylaminobutyric acid ethyl ester

: 1359874-78-4
5-[[[1-(tert-butoxycarbonylaminomethyl)-2-ethoxycarbonyl-ethyl]benzyloxycarbonylamino]methyl]-4,5-dihydro-isoxazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; toluene / 0.17 h / -20 °C

1.2: 1 h / -20 °C

2.1: triphenylphosphine / tetrahydrofuran; water / 12 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: sodium hydrogencarbonate / ethyl acetate / 12 h / 20 °C

With sodium hydrogencarbonate; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol203433c

Reference yield:

: 1359874-76-2
(S)-3-[(N-allyl)benzyloxycarbonylamino]-4-azidobutyric acid ethyl ester

: 1359874-78-4
5-[[[1-(tert-butoxycarbonylaminomethyl)-2-ethoxycarbonyl-ethyl]benzyloxycarbonylamino]methyl]-4,5-dihydro-isoxazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine / tetrahydrofuran; water / 12 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: sodium hydrogencarbonate / ethyl acetate / 12 h / 20 °C

With sodium hydrogencarbonate; triphenylphosphine; In tetrahydrofuran; water; ethyl acetate;
DOI:10.1021/ol203433c