5-(4-chloro-8-(trifluoromethyl)quinolin-3-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol

Base Information

Chemical Name:5-(4-chloro-8-(trifluoromethyl)quinolin-3-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol
CAS No.:1198229-69-4
Molecular Formula:C₁₈H₁₀ClF₃N₄S
Molecular Weight:406.818
Hs Code.:

Synonyms:5-(4-chloro-8-(trifluoromethyl)quinolin-3-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(4-chloro-8-(trifluoromethyl)quinolin-3-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol

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Technology Process of 5-(4-chloro-8-(trifluoromethyl)quinolin-3-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol

There total 1 articles about 5-(4-chloro-8-(trifluoromethyl)quinolin-3-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1198229-66-1
8-(trifluoromethyl)-3-(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)quinolin-4-ol

: 1198229-69-4
5-(4-chloro-8-(trifluoromethyl)quinolin-3-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol

Guidance literature:: With trichlorophosphate; at 60 ℃; for 2h;
DOI:10.1016/j.ejmech.2009.06.031

Reference yield: 91.0%

: 7037-49-2
3-(piperidin-4-yl)propan-1-ol

: 1198229-69-4
5-(4-chloro-8-(trifluoromethyl)quinolin-3-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol

: 1198229-81-0
3-(1-(8-(trifluoromethyl)-3-(5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)quinolin-4-yl)piperidin-4-yl)propan-1-ol

Guidance literature:: With potassium carbonate; In acetonitrile; at 120 ℃; for 0.166667h; Microwave irradiation; Inert atmosphere;
DOI:10.1016/j.ejmech.2009.06.031

Reference yield: 91.0%

: 1198229-69-4
5-(4-chloro-8-(trifluoromethyl)quinolin-3-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol

: 108-91-8,157973-60-9
cyclohexylamine

: 1198229-79-6
5-(4-(cyclohexylamino)-8-(trifluoromethyl)quinolin-3-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol

Guidance literature:: With potassium carbonate; In acetonitrile; at 120 ℃; for 0.166667h; Microwave irradiation; Inert atmosphere;
DOI:10.1016/j.ejmech.2009.06.031