methyl 2-(4-(4-bromophenyl)-4-hydroxycyclohexylidene)acetate

Base Information

• Chemical Name: methyl 2-(4-(4-bromophenyl)-4-hydroxycyclohexylidene)acetate
• CAS No.: 1477524-72-3
• Molecular Formula: C₁₅H₁₇BrO₃
• Molecular Weight: 325.202
• Mol file: 1477524-72-3.mol

Synonyms:methyl 2-(4-(4-bromophenyl)-4-hydroxycyclohexylidene)acetate

Chemical Property of methyl 2-(4-(4-bromophenyl)-4-hydroxycyclohexylidene)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(4-(4-bromophenyl)-4-hydroxycyclohexylidene)acetate

There total 4 articles about methyl 2-(4-(4-bromophenyl)-4-hydroxycyclohexylidene)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trimethyl phosphonoacetate (5927-18-4) + 4-(4-bromophenyl)-4-hydroxycyclohexan-1-one (1477524-71-2) → methyl 2-(4-(4-bromophenyl)-4-hydroxycyclohexylidene)acetate (1477524-72-3) + methyl 2-(4-(4-bromophenyl)-7-oxabicyclo[2.2.1]heptan-1-yl)acetate (1477524-73-4)

Guidance literature:

trimethyl phosphonoacetate; With sodium hydride; In methanol; mineral oil; at 20 ℃; for 0.5h;

4-(4-bromophenyl)-4-hydroxycyclohexan-1-one; In methanol; mineral oil; at 20 ℃; for 20h;

Reference yield:

4-Hydroxy-4-(p-bromophenyl)cyclohexanone ethylene ketal (125962-59-6) → methyl 2-(4-(4-bromophenyl)-4-hydroxycyclohexylidene)acetate (1477524-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / acetone; water / 1 h / 75 °C

2.1: sodium hydride / methanol; mineral oil / 0.5 h / 20 °C

2.2: 20 h / 20 °C

With sodium hydride; toluene-4-sulfonic acid; In methanol; water; acetone; mineral oil; 2.1: |Wittig Olefination / 2.2: |Wittig Olefination;

Reference yield:

1.4-dibromobenzene (106-37-6) → methyl 2-(4-(4-bromophenyl)-4-hydroxycyclohexylidene)acetate (1477524-72-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: magnesium; iodine / tetrahydrofuran / 0.5 h / 20 °C

1.2: 15.33 h / -78 - 20 °C

2.1: toluene-4-sulfonic acid / acetone; water / 1 h / 75 °C

3.1: sodium hydride / methanol; mineral oil / 0.5 h / 20 °C

3.2: 20 h / 20 °C

With iodine; sodium hydride; toluene-4-sulfonic acid; magnesium; In tetrahydrofuran; methanol; water; acetone; mineral oil; 3.1: |Wittig Olefination / 3.2: |Wittig Olefination;

upstream raw materials:

1.4-dibromobenzene

cyclohexanedione monoethylene ketal

4-Hydroxy-4-(p-bromophenyl)cyclohexanone ethylene ketal

trimethyl phosphonoacetate

Downstream raw materials:

methyl 2-(4-(4-bromophenyl)-7-oxabicyclo[2.2.1]heptan-1-yl)acetate

methyl 2-(4-(4'-((5-(tert-butyl)-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-7-oxabicyclo[2.2.1]heptan-1-yl)acetate

2-(4-(4'-((5-(tert-butyl)-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-7-oxabicyclo[2.2.1]heptan-1-yl)acetic acid