(S)-5-Dibenzylamino-2-(4-fluoro-benzyl)-6-methyl-4-oxo-heptanoic acid ethyl ester

Base Information

Chemical Name:(S)-5-Dibenzylamino-2-(4-fluoro-benzyl)-6-methyl-4-oxo-heptanoic acid ethyl ester
CAS No.:848617-65-2
Molecular Formula:C₃₁H₃₆FNO₃
Molecular Weight:489.63
Hs Code.:

Synonyms:(S)-5-Dibenzylamino-2-(4-fluoro-benzyl)-6-methyl-4-oxo-heptanoic acid ethyl ester

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Chemical Property of (S)-5-Dibenzylamino-2-(4-fluoro-benzyl)-6-methyl-4-oxo-heptanoic acid ethyl ester

Chemical Property:

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Technology Process of (S)-5-Dibenzylamino-2-(4-fluoro-benzyl)-6-methyl-4-oxo-heptanoic acid ethyl ester

There total 3 articles about (S)-5-Dibenzylamino-2-(4-fluoro-benzyl)-6-methyl-4-oxo-heptanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 848617-63-0
(E)-(S)-5-Dibenzylamino-2-(4-fluoro-benzyl)-6-methyl-4-oxo-hept-2-enoic acid ethyl ester

: 848617-65-2
(S)-5-Dibenzylamino-2-(4-fluoro-benzyl)-6-methyl-4-oxo-heptanoic acid ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 5h; under 760 Torr;
DOI:10.1016/j.tetasy.2004.11.092

Reference yield:

: 111060-51-6
(S)-benzyl 2-(dibenzylamino)-3-methylbutanoate

: 848617-65-2
(S)-5-Dibenzylamino-2-(4-fluoro-benzyl)-6-methyl-4-oxo-heptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: BuLi / tetrahydrofuran; hexane / 0.5 h

1.2: tetrahydrofuran / 3.33 h / -78 - 20 °C

2.1: NaH / various solvent(s); tetrahydrofuran / 18 h / 20 °C

3.1: 5.8 g / H₂ / Pd/C / ethanol / 5 h / 760 Torr

With n-butyllithium; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; 2.1: Horner-Emmons reaction;
DOI:10.1016/j.tetasy.2004.11.092

Reference yield:

: 452920-98-8
dimethyl (3S)-[3-(dibenzylamino)4-methyl-2-oxopentyl]phosphonate

: 848617-65-2
(S)-5-Dibenzylamino-2-(4-fluoro-benzyl)-6-methyl-4-oxo-heptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / various solvent(s); tetrahydrofuran / 18 h / 20 °C

2: 5.8 g / H₂ / Pd/C / ethanol / 5 h / 760 Torr

With hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; 1: Horner-Emmons reaction;
DOI:10.1016/j.tetasy.2004.11.092